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    Evaluation of Electrocardiographic and Echocardiographic Findings In Patients Diagnosed with Polycythemia Vera and Essential Thrombocythemia
    (Selçuk Üniversitesi, 2024 Şubat) Kaya, Bahattin Engin; Demircioğlu, Sinan; Tekinalp, Atakan; Sertdemir, Ahmet Lütfi; Ergün, Mustafa Çağrı; Tuna, Ali Kürşat; Kandemir, Şerif Ahmet; İçli, Abdullah; Çeneli, Özcan
    ABSTRACT Background/Aims: Polycythemia vera (PV) and essential thrombocythemia (ET) are chronic myeloproliferative diseases that can lead to various clinical outcomes, including arterial and venous thrombosis, pulmonary hypertension, and myocardial infarction. This study was designed to assess the cardiac effects of these diseases using electrocardiography and echocardiography. Methods: A total of 50 patients diagnosed with PV, 50 patients diagnosed with ET, and 50 healthy individuals forming the control group were enrolled in this study. Demographic information for all subjects was collected. Electrocardiography (ECG) recordings and standard transthoracic echocardiographic examinations were conducted for all patients and control subjects. Pulse wave velocity (PWV) measurements were assessed using a Holter blood pressure device. Results: In total, 50 PV patients, 50 ET patients, and 50 control group were included in the study. The demographic characteristics of the PV, ET and control groups were similar. The PR interval was significantly shorter in control subjects than in PV and ET patients (p = 0.007, p = 0.024). Although the measured values were within normal limits, diastolic posterior wall thickness was significantly lower in the control group compared to PV and ET patients (p = 0.019, p = 0.009). PWV was significantly higher in ET patients compared to the control group (p = 0.012). Conclusion: ECG parameters used to predict ventricular arrhythmias (QT, QTc, Tp-Te, Tp-Te/QT) and Pulmonary Artery Pressure showed no significant change, in opposition to existing literature. Nonetheless, similar to previous publications, PV and ET were found to negatively affect the diastolic function parameters on transthoracic echocardiography. While the aortic stiffness was significantly higher in ET patients compared to the control group, no significant difference was noted between PV patients and control subjects in terms of aortic stiffness.
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    Impact of Hemoglobin, Leucocyte and Thrombocyte Levels at Diagnosis on the Survival Outcomes of Chronic Myeloid Leukemia Patients
    (Selçuk Üniversitesi, 2024 Şubat) Demircioğlu, Sinan; Çiftçiler, Rafiye; Kars, Taha Ulutan; Tekinalp, Atakan
    Background: Since the development of tyrosine kinase inhibitors (TKIs), the prognosis for chronic myeloid leukemia (CML) has significantly improved. Several predicted prognostic scores and indicators at diagnosis have been used to predict the prognosis of chronic phase chronic myeloid leukemia (CML-CP) during the TKI period. When CML patients are first diagnosed, hemogram parameter aberrations are rather prevalent in clinical practice although it is still unknown how those parameters affect the prognosis. This study aims to evaluate the hemogram parameters at diagnosis on the survival outcomes of CML-CP patients. Materials and Methods: One hundred thirty-seven patients who were diagnosed with CML-CP and received treatment were assessed between the years 2006 and 2020. Results: There were 65 (47.4%) males and 72 (52.6%) females with a median age of 50 (range: 18-78) years at diagnosis. Median hemoglobin level was 12.1 gr/dL (4.3-17.4), leucocyte count was 66.2 ×109 /L (7.5-520.2), and thrombocyte count was 362 ×109 /L (18-3.496) for all patients. The median progression-free survival (PFS) was 16.7 (2.0-106.4) months and the median overall survival (OS) was 63.8 (0.43-166.2) months for all patients. Conclusion: This study is valuable in terms of predicting the prognosis of CML patients with hemoglobin, leukocyte, and platelet values at the time of diagnosis. While emphasizing the importance of platelet count at the time of diagnosis, similar to the previously defined risk scores, it showed that leukocyte and hemoglobin values at the time of diagnosis did not have a statistically significant effect on OS and PFS.