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Öğe Assessment of concomitant versus sequential trastuzumab on radiation-induced cardiovascular toxicity(SAGE PUBLICATIONS LTD, 2017) Yavas, G.; Gultekin, M.; Yildiz, O.; Seyrek, M.; Demirkol, S.; Toy, H.; Sargon, M. F.There are limited data regarding effect of trastuzumab on radiation-induced cardiovascular toxicity when used sequentially or concomitantly. This experimental study aims to investigate effect of trastuzumab on radiation-induced cardiovascular toxicity with respect to the treatment sequence. One hundred and eight female Wistar albino rats were divided into six groups (G): G1 was control, G2 was trastuzumab, and G3 was radiotherapy (RT); G4 and G6 were sequential RT and trastuzumab; and G5 was concomitant RT and trastuzumab groups, respectively. Rats were killed at 6th h, 21st and 70th days after RT; thoracic aorta and heart samples were obtained. Transthoracic echocardiography and functional studies evaluating relaxation of thoracic aorta were performed. Subendothelial edema scores of thoracic aorta samples at 21st and 70th days were higher in RT groups (G3, G4, G5, and G6) (p < 0.001). There was a deterioration of relaxation responses of thoracic aorta samples in RT groups (p < 0.001). Cardiac fibrosis (CF) scores revealed detrimental effect of RT beginning from 6th h and trastuzumab from 21st day. RT groups showed further deterioration of CF at 70th day. Ejection fraction, left ventricular mass, and fractional shortening were significantly decreased in G4, G5, and G6. Trastuzumab may increase pathological damage in cardiovascular structures when used with RT regardless of timing.Öğe ATTENTION DEFICIT HYPERACTIVITY DISORDER IN WOMEN WITH POLYCYSTIC OVARY SYNDROME(ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER, 2012) Herguner, S.; Harmanci, H.; Toy, H.[Abstract not Available]Öğe COMPARISON OF DIMENHYDRINATE, METOCLOPRAMIDE AND PLACEBO FOR PREVENTION OF POSTOPERATIVE NAUSEA AND VOMITING AFTER INTRATHECAL MORPHINE(WILEY-BLACKWELL, 2011) Duman, A.; Apiliogullari, S.; Gok, F.; Sutcu, E.; Soysal, S.; Toy, H.[Abstract not Available]Öğe A comparison of liquid-based cytology with conventional cytology(ELSEVIER IRELAND LTD, 2008) Celik, C.; Gezginc, K.; Toy, H.; Findik, S.; Yilmaz, O.Objective: To evaluate the 2 methods of cytologic screening to detect abnormalities of the cervical epithelium. Methods: This study with 3 groups of women was performed at Selcuk University Meram Medical School between January 2004 and March 2006. In one group (paired sample for specimen collection) women were screened with conventional cytology; in another group (paired sample for specimen collection) they were screened with liquid-based cytology; and in the third group (split sample for specimen collection) they were screened by both methods. Results: The rate of unsatisfactory results was lower in the liquid-based than in the conventional cytology group (6.1% vs. 2.6%; P < 0.05). More smears containing atypical squamous cells of undetermined significance were detected by the liquid-based method, but the difference was not statistically significant. Also, no statistically significant differences between liquid-based and conventional cytology were observed in the detection of other epithelial abnormalities (P > 0.05). Conclusion: The liquid-based and conventional cytology methods were found to be equivalent in the detection of cervical epithelial abnormalities. (c) 2007 International Federation of Gynecology and Obstetrics. Published by Elsevier Ireland Ltd. All rights reserved.Öğe Confluent and reticulated papillomatosis associated with polycystic ovary syndrome treated with a combined contraceptive containing drospirenone(WILEY, 2009) Oezdemir, S.; Oezdemir, M.; Toy, H.[Abstract not Available]Öğe Correliation Between Osteopontin Protein Expression and Histological Grade of Astrocytomas(SPRINGER, 2009) Toy, H.; Yavas, O.; Eren, O.; Genc, M.; Yavas, C.Osteopontin is a ligand for the integrin proteins, which are cell surface receptors that mediate the physical and functional interactions between a cell and the extracellular matrix. The expression of osteopontin is reportedly increased in a number of transformed cell lines and tumor tissues. Furthermore, increased expression of osteopontin results in some infiltrative features of tumors. The aim of the study is to demonstrate that expression of osteopontin in human astrocytomas correlates with histological tumor grade. The expression of osteopontin in human astrocytomas was determined with immunohistochemistry. Median osteopontin expression levels were 1%, 7.5%, 60%, and 50% in grade I, II, III, and IV tumors, respectively. Osteopontin staining was significantly higher in high grade (grade III-IV) than low grade (grade I-II) tumors. These findings indicate that osteopontin immunoreactivity in human astrocytomas may correlate with the grade of a tumor.Öğe Expression of cyclin A, cyclin E and p27 in normal, hyperplastic and frankly malignant endometrial samples(INFORMA HEALTHCARE, 2013) Gezginc, S. T.; Celik, C.; Dogan, N. U.; Toy, H.; Tazegul, A.; Colakoglu, M. C.Cellular growth is under the control of certain molecules such as cyclins and cyclin dependent kinases. Dysregulation of these proteins disrupt cell cycle and may trigger malignant transformation. Cyclins and kinase inhibitors also play essential roles in endometrial cellular proliferation. But the exact roles of these mediators in the disease process is not clear. We evaluated expression of cyclin A, cyclin E and p27 in normal, hyperplastic and malignant endometrial samples assuming different expression patterns in physiological and pathological processes. A total of 75 patients with histopathological diagnosis of normal proliferative, hyperplastic or malignant endometrial samples were evaluated with different cellular proliferation markers, cyclin A, cyclin E and p27. For cyclin E, endometrial cancer samples had higher rate of immunoreactivity than normal proliferative and hyperplastic endometrial samples. Staining properties for cyclin A were comparable for three groups. However, p27 immunoreactivity decreased progressively as lesions progress from proliferative benign endometrium to frank carcinoma. Further large-scale studies with clinical follow-up will reveal the exact role of cyclins on endometrial carcinogenesis.Öğe Gallbladder Motor Function in Patients with Different Thyroid Hormone Status(JOHANN AMBROSIUS BARTH VERLAG MEDIZINVERLAGE HEIDELBERG GMBH, 2009) Cakir, M.; Kayacetin, E.; Toy, H.; Bozkurt, S.Hypothyroidism and hyperthyroidism are known to affect cholesterol metabolism, bile acid synthesis and bile content. There are previous Studies reporting increased prevalence of gallstone and common bile duct stone formation in hypothyroidism. The aim Of this Study was to compare gallbladder (GB) motor function between euthyroid, hypothyroid and hyperthyroid Subjects by conventional ultrasonography. Eighteen euthyroid, 14 hypothyroid and 20 hyperthyroid, age, sex and body mass index matched subjects were included in the study. Etiology of hypothyroidism comprised of thyroidectomy, Hashimoto's thyroiditis and previous radioactive iodine therapy. Hyperthyroid group included patients with toxic nodular goitre and Graves' disease. Patients who have diseases or are under drug treatment known to affect biliary function were not included in the study. Fasting and post-stimulus GB volumes were measured by real-time conventional ultrasonography and computer unit (Aloka UST-979, 3.5 mHz electronic convex probe, Japan). No significant differences were noted for fasting, post-stimulus GB volumes and GB ejection fraction between euthyroid, hypothyroid and hyperthyroid subjects. Measuring GB motility accurately is not straightforward because besides being not static during fasting, after a meal, intermittent emptying and refilling of GB occurs. Ultrasonography is affected by GB filling and measures "net" GB emptying. Although cumbersome, additional evaluation with cholescintigraphy which detects "absolute" GB emptying and is not affected by GB filling may provide complete assessment of motor function and may be more informative in evaluating subjects with different thyroid hormone status.Öğe Histological effects of zinc and melatonin on rat testes(COMENIUS UNIV, 2011) Tuncer, I; Sunar, F.; Toy, H.; Baltaci, A. K.; Mogulkoc, R.Background: The objective of this study is to examine the histological effects of zinc and melatonin, alone or in combination, on rat testes. Methods: For this purpose four study groups of ten Sprague-Dawley male rats were formed and treated for one month as follows: (1) Controls; (2) Rats injected with 3 mg/kg/day zinc, as zinc sulfate; (3) Rats injected with 3 mg/kg/day melatonin and (4) Rats injected with 3 mg/kg/day each zinc and melatonin. Results: After four weeks the rats treated with melatonin showed inhibited spermatogenesis, testicular tubular degeneration and necrosis, obstruction of tubular lumen and lymphocytic infiltration. The two zinc-treated groups showed no histological differences to controls but the melatonin-only group showed inhibited spermatogenetic activity, tubular degeneration and necrosis, as well as obstruction of tubule lumens and lymphocytic infiltration. Conclusion: The obtained results suggest that 4-week treatment with melatonin leads to histological and physiological impairments of testis and that zinc supplementation might offset these damaging effects (Tab. 2, Fig. 4, Ref. 12). Full Text in free PDF www.bmj.sk.Öğe The impact of estrogen supplementation on IVF outcome in patients with polycystic ovary syndrome(OXFORD UNIV PRESS, 2011) Colakoglu, M.; Toy, H.; Icen, M. S.; Vural, M.; Mahmoud, A. S.; Yazici, F.[Abstract not Available]Öğe Narrow-band ultraviolet B phototherapy for the treatment of vitiligo: evidence against an autoimmune pathogenesis(WILEY-BLACKWELL, 2008) Engin, B.; Baysal, I.; Reisli, I.; Ozdemir, M.; Toy, H.[Abstract not Available]Öğe Protective role of zinc pretreatment in hepatotoxicity induced by halothane(CAMBRIDGE UNIV PRESS, 2008) Unsal, C.; Celik, J. B.; Toy, H.; Esen, H.; Otelcioglu, S.Background and objective: This study was designed to determine the protective effects of zinc on halothane-induced hepatotoxicity. Methods: Forty-five male Sprague-Dawley rats were divided into three groups. The hatothane group received normal drinking water and diet; the zinc-halothane group received 227 mgL(-1) zinc sulphate in the drinking water and diet for 2 weeks; and the control group received normal diet and water. At the end of 2 weeks, rats were housed in an anaesthesia box and 1 MAC (minimum alveolar concentration) halothane was administered at 6 L min(-1) in room air for 2 h. This was repeated 48 h later. After the rats were scrificed, we measured alkaline phosphatase, aspartate aminotransferase, alanine aminotransferase, glutamyl transpeptidase, glutathione-S-transferase, serum electrolytes and bilirubin in samples. The degree of liver toxicity was assessed by light microscopic examination. Results: We demonstrated a reduction of alanine aminotransferase, aspartate amino transferase, glutathione-S-transferase levels and a reduction in liver damage in the zinc-halothane group. Conclusion: The study concludes that zinc has the potential to alleviate the toxic effects of halothane in rat liver.Öğe Treatment of plaque-type localized scleroderma with retinoic acid and ultraviolet A plus the photosensitizer psoralen: a case series(WILEY, 2008) Oezdemir, M.; Engin, B.; Toy, H.; Mevlitoglu, I.[Abstract not Available]Öğe The use of concurrent hormonotherapy and radiotherapy does not deteriorate radiation-induced cardiac toxicity(SAGE PUBLICATIONS LTD, 2017) Yavas, C.; Yavas, G.; Toy, H.; Ata, O.Postmenopausal patients with breast cancer have two options for adjuvant endocrine therapy, tamoxifen and aromatase inhibitors (AIs) as well as radiotherapy (RT) and chemotherapy. However, there is limited data regarding the optimal sequencing of RT and tamoxifen/AIs. Thus, we aimed to evaluate the effects of tamoxifen and AIs on radiation-induced cardiotoxicity. Eighty ovariectomized rats were divided into eight groups (G). G1 was defined as a control group; G2, G3, G4, and G5 were RT, tamoxifen, anastrozle, and letrozole groups, respectively; G6, G7, and G8 were RT plus tamoxifen, anastrozle, and letrozole groups, respectively. Drugs were started 1 week before RT and continued until the animals were killed 16 weeks after RT. The heart tissues were then dissected and examined with light microscopy to determine endocardial thickness and cardiac fibrosis. The endocardial thickness scores of both RT alone and the tamoxifen groups as well as the cardiac fibrosis score of RT alone were higher than that the control group (p < 0.05 for all). There was no difference in the endocardial thickness and cardiac fibrosis scores of the RT-only group and the RT plus hormonotherapy groups (p > 0.05 for all). Concurrent administration of RT and hormonal therapy with either tamoxifen or AIs did not further amplify radiation-induced cardiac toxicity. This issue warrants further study.
