Protective role of zinc pretreatment in hepatotoxicity induced by halothane
Küçük Resim Yok
Tarih
2008
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
CAMBRIDGE UNIV PRESS
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Background and objective: This study was designed to determine the protective effects of zinc on halothane-induced hepatotoxicity. Methods: Forty-five male Sprague-Dawley rats were divided into three groups. The hatothane group received normal drinking water and diet; the zinc-halothane group received 227 mgL(-1) zinc sulphate in the drinking water and diet for 2 weeks; and the control group received normal diet and water. At the end of 2 weeks, rats were housed in an anaesthesia box and 1 MAC (minimum alveolar concentration) halothane was administered at 6 L min(-1) in room air for 2 h. This was repeated 48 h later. After the rats were scrificed, we measured alkaline phosphatase, aspartate aminotransferase, alanine aminotransferase, glutamyl transpeptidase, glutathione-S-transferase, serum electrolytes and bilirubin in samples. The degree of liver toxicity was assessed by light microscopic examination. Results: We demonstrated a reduction of alanine aminotransferase, aspartate amino transferase, glutathione-S-transferase levels and a reduction in liver damage in the zinc-halothane group. Conclusion: The study concludes that zinc has the potential to alleviate the toxic effects of halothane in rat liver.
Açıklama
Anahtar Kelimeler
halothane, zinc, rat, liver, toxicity
Kaynak
EUROPEAN JOURNAL OF ANAESTHESIOLOGY
WoS Q Değeri
Q3
Scopus Q Değeri
Q1
Cilt
25
Sayı
10
