Protective role of zinc pretreatment in hepatotoxicity induced by halothane

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dc.contributor.authorUnsal, C.
dc.contributor.authorCelik, J. B.
dc.contributor.authorToy, H.
dc.contributor.authorEsen, H.
dc.contributor.authorOtelcioglu, S.
dc.date.accessioned2020-03-26T17:27:32Z
dc.date.available2020-03-26T17:27:32Z
dc.date.issued2008
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractBackground and objective: This study was designed to determine the protective effects of zinc on halothane-induced hepatotoxicity. Methods: Forty-five male Sprague-Dawley rats were divided into three groups. The hatothane group received normal drinking water and diet; the zinc-halothane group received 227 mgL(-1) zinc sulphate in the drinking water and diet for 2 weeks; and the control group received normal diet and water. At the end of 2 weeks, rats were housed in an anaesthesia box and 1 MAC (minimum alveolar concentration) halothane was administered at 6 L min(-1) in room air for 2 h. This was repeated 48 h later. After the rats were scrificed, we measured alkaline phosphatase, aspartate aminotransferase, alanine aminotransferase, glutamyl transpeptidase, glutathione-S-transferase, serum electrolytes and bilirubin in samples. The degree of liver toxicity was assessed by light microscopic examination. Results: We demonstrated a reduction of alanine aminotransferase, aspartate amino transferase, glutathione-S-transferase levels and a reduction in liver damage in the zinc-halothane group. Conclusion: The study concludes that zinc has the potential to alleviate the toxic effects of halothane in rat liver.en_US
dc.identifier.doi10.1017/S0265021508004523en_US
dc.identifier.endpage815en_US
dc.identifier.issn0265-0215en_US
dc.identifier.issue10en_US
dc.identifier.pmid18533074en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage810en_US
dc.identifier.urihttps://dx.doi.org/10.1017/S0265021508004523
dc.identifier.urihttps://hdl.handle.net/20.500.12395/22589
dc.identifier.volume25en_US
dc.identifier.wosWOS:000259713500006en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherCAMBRIDGE UNIV PRESSen_US
dc.relation.ispartofEUROPEAN JOURNAL OF ANAESTHESIOLOGYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjecthalothaneen_US
dc.subjectzincen_US
dc.subjectraten_US
dc.subjectliveren_US
dc.subjecttoxicityen_US
dc.titleProtective role of zinc pretreatment in hepatotoxicity induced by halothaneen_US
dc.typeArticleen_US

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