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Öğe Anti-inflammatory and anti-fibrotic effects of sirolimus on bleomycininduced pulmonary fibrosis in rats(2011) Tulek B.; Kiyan E.; Toy H.; Kiyici A.; Narin C.; Suerdem M.Purpose: Pulmonary fibrosis is a devastating disease with a poor prognosis. Although the diagnosis and pathophysiology of this disease have been better characterized over the past few years, there is no effective therapy for the disease. The aim of this study was to evaluate the anti-inflammatory and anti-fibrotic effects of sirolimus (SRL), which is a potential anti-fibrotic agent, by using bleomycin (BLM)-induced pulmonary fibrosis model in rats. Methods: A single intra-tracheal injection of BLM (2.5 U/kg) was administered and sirolimus (2.5 mg/kg/day) was given orally, beginning either one day before (early SRL) or nine days after (late SRL) the BLM administration. The effect of SRL on fibrosis was studied by analysis of cytokine levels in BAL fluid, measurement of lung tissue hydroxyproline (HPL) content and histopathological examination. Results: Both early and late SRL administrations caused a decrease in the levels of IL-13, PDGF-A and TGF-?1 (p=0.001) and an increase in IFN-? levels (p=0.001) in BAL fluid. Early and late SRL also caused a decrease in HPL content (p=0.001). Early sirolimus caused a significant decrease in fibrosis score (p=0.001), while late SRL did not. Conclusion: Sirolimus was effective in BLM-induced pulmonary fibrosis model, especially in the early phases of the disease. © 2011 CIM.Öğe Coexistence of Glomangioma and yolk sac tumour in a child: A case report(Journal of Clinical and Diagnostic Research, 2014) Kose D.; Toy H.; Gunel E.; Caliskan U.; Koksal Y.Glomus tumours (GTs) primarily arise from glomus bodies that are located in the dermis layer of skin. However, they can be encountered ectopically in most parts of the body. As a result of researches done in a 17-month-old male patient who prssented to us with complaint of an increasingly growing swelling, he was diagnosed with a yolk sac tumour. Chemotherapy was started and then, he was operated. GT was found inside the tumoural mass. Our patient, who is the first case according to our knowledge, where the concurrence of yolk sac and glomus tumours was reported, has been discussed in the light of literature.Öğe Cutaneous metastasis of pleural malignant mesothelioma [Plevral malin mezotelyoma deri metastazi](2007) Özdemir M.; Gümüflel M.; Toy H.Pleural malignant mesothelioma is a rare tumor. Metastasis of malignant mesothelioma is through both local invasion and hematogenous routes and occurs at various stages of the disease. In this article, we present a case with cutaneous metastasis of plural malignant mesothelioma, which is rarely seen and review the literature on skin metastasis of malignant mesothelioma.Öğe Effect of oral immunoglobulin G in experimental necrotizing enterocolitis model [Deneysel nekrotizan enterokolit modelinde agizdan verilen immünglobülin G'nin etkisi](2008) Yurtçu M.; Aydogdu B.; Toy H.; Gürbílek M.; Günel E.Aim: Investigation of the protective effect of oral immunglobulin(Ig) G on rat intestinum in experimental necrotizing enterocolitis model. Materials and Methods: 40 newborn rats were devided into 4 groups each containing 10 rats. While control (C) group was fed by breast, the rats in necrotizing enterocolitis (N), sham (S), and treatment (T) groups were settled into incubators at 36°C and 60 % humidity and fed, but not by breast. The rats in group C were breast fed. The rats in N group were fed with Formula as soon as they were born. The rats in T group were fed with Formula and 1200 mg/kg/day oral Ig A with 4-hour intervals. The rats in S group were fed with Formula and 0.1 ml/kg/day distilled water which is solvent of Ig. The rats in all groups were weighed and sacrified on fourth day. 2 cm intestinal segment from proximal of ileocaecal valve was used for histopathologic examination, another 10 cm intestinal segment for biochemical examination. After laparotomy, H&E was used for histopathological examination and apoptosis repressor with card Ab-1 citt for immunohistochemical examination. Biochemical parameters such as TNF-?, and IL-6 were evaluated. Results: The rate of mortality in N, S, and T groups was significantly higher than groups C (P=0.038). Significant weight increase in group C was significantly higher than N, S, and T groups (P=0.000). Histopathologic parameters such as villus injury, transmural necrosis in group C were found to be significantly decreased compared with N, S, and T groups according to scoring system (P=0.000). Apoptosis in group C was found to be significantly decreased compared with N, S, and T groups according to scoring system (P=0.001). IL-6 and TNF-? levels were identified to be significantly decreased in group C compared with N, S, and T groups (P<0.05). There was no significant difference among N, S, and T groups (P>0.05). Conclusion: Pure IgG given orally was not identified to decrease intestinal damage and to prevent NEC in experimental NEC model both biochemically and histopathologically.Öğe The effects of desflurane, sevoflurane and propofol anaesthesia on bronchoalveolar lavage cells [Propofol, desfluran ve sevofluran anestezisinin bronkoalveolar lavaj hücreleri üzerine etkisi](2005) Çiçekci F.; Reisli R.; Toy H.; Sarkilar G.; Otelcio?lu Ş.This study compared the effects of desflurane, sevoflurane and propofol anaesthesia on alveolar macrophage, PMNL, bronchial epithelia cells and morphological structure. Sixty patients varying in age between 18 and 60 and scheduled to undergo extremity surgery were included in the study. Patients were randomly allocated to three groups consisting of 20 patients each. In all groups, general anesthesia was induced with 2-3 mg kg-1 of propofol, 1?g kg-1 of fentanyl, 0.6 mg kg-1 of rocuronium bromide. Anesthesia was maintained with 6% desflurane (Group D) and 2% sevoflurane (Group S) to obtain 1 MAC. In Group P, propofol infusion was started with a dose of 12 mg kg-1 h-1, which was reduced to 9, 6 and then 4 mg kg-1 at 20 minute intervals after the first dose. All patients were given 50% O2-50% dry air 4 L min-1. As required, patients were given rocuronium 0.2 mg kg-1, fentanyl 1?g kg-1. Bronchoalveolar lavage fluid (BAL) was collected following induction of anesthesia (T0) and at the 120th minute of the operation (T1). Mature and immature alveolar macrophages, PMNL and brochial epithelial cells in T0 and T1 preparation were counted under a light microscope. Comparison within each group indicated that there was a statistically significant difference in time dependent increase on PMNL augmentation and a decrease in bronchial epithelial cells. We concluded that during the two hour period of anesthesia and the operation, no changes were detected in bronchoalveolar lavage cells in the groups. As a result, we can say that no group showed superiority over the others. Further studies are needed to explain the time dependent increase in PMNL.Öğe Endourological treatment of bladder leiomyoma(2008) Öztürk A.; Piskin M.M.; Arslan M.; Güven S.; Toy H.; Serarslan A.Leiomyoma is a benign, mesenchymal tissue originated, rare tumor of the bladder. Mostly, bladder leiomyomas are asymptomatic and found incidentally. A female predominance is found. We describe a female patient with leiomyoma of the bladder who presented with pelvic pain and in whom bladder preserving surgery was performed. The literature is reviewed and the management is discussed.Öğe Melanotic neuroectodermal tumor of infancy in the maxilla: A case report(Elsevier Ireland Ltd, 2011) Yildirim G.; Çalişkan U.; Neslihan Akça C.; Dolanmaz D.; Toy H.Melanotic neuroectodermal tumor of infancy (MNTI) is an uncommon, fast-growing, pigmented neoplasm of neural crest origin; it primarily affects the maxilla of the infants during the first year of life, but it may also occur in the mandible, skull, brain, epididymis, and other rare locations. In this case, a 5-months old male infant with MNTI on the right anterior maxillary alveolar ridge and its treatment was presented. The patient underwent complete surgical resection without maxillectomy. There has been no recurrence in a follow-up period of 21 months. © 2011 Elsevier Ireland Ltd. All rights reserved.Öğe A multiple myeloma case presenting with bilateral pleural involvement [Bilateral plevral tutulum ile başvuran multipl miyelom olgusu](2007) Yosunkaya Ş.; Maden E.; Toy H.; Yazici R.; Özer F.; Reisli I.Pleural effusion is a relatively infrequent finding in multiple myeloma (MM) and malign effusions due to myelomatous effusion is seen very rarely. In this article we reported a case with bilateral myelomatous effusion. Myelomatous etiology was detected by demonstrating gammopaty in pleural fluid protein electrophoresis and demonstrating abundant number of atypical plasma cells in pleural fluid cytology. Pleural fluids due to MM are usually seen in IgA type of MM's, IgG on the surface of CD-138 positive cell was demonstrated in flow cytometric study of the pleural fluid of the reported case. In conclusion we mentioned that a patient who does not have diagnosis of MM before may present with pleural involvement, the involvement may be bilateral and flow cytometry can be used in diagnosis.Öğe Neuroblastoma in an infant with Down’s syndrome [Neuroblastoma in un bambino con sindrome di Down](Mattioli 1885 S.p.A., 2014) Kose D.; Toy H.; Yıldırım M.S.; Yavuz H.; Koksal Y.Aim: In this study we show that Down’s syndrome may be accompanied by neuroblastoma. Patients and methods: A 15-month-old female infant with Down’s syndrome and congenital hypothyroidism was admitted to our hospital with abdominal distension. Abdomen ultrasound (US) and computed tomography (CT) revealed right abdominal mass. The level of urinary homovanillic acid was 498.2 mg/24 h (N: 2-7.4 mg/24 h), and the serum neuron specific enolase (NSE) level was 370 ng/mL (N: 4.7-17 ng/mL). Karyotyping revealed 47 XX+21 chromosome, consistent with the diagnosis of Down’s syndrome. Bone marrow aspirates revealed metastatic neuroblastoma. On the basis of these findings, the patient was diagnosed with stage IV neuroblastoma. The patient was treated as stage IV neuroblastoma according to our national neuroblastoma protocol which included 4 cycles of 2 different multidrug regimens and then the mass was totally removed. After the operation, two cycles of chemotherapy were administered. However, the patient died of pneumonia. Results: We here describe a case of Down’s syndrome associated with neuroblastoma. Conclusions: Neuroblastoma in Down’s syndrome is extremely rare. Although children with Down’s syndrome are protected by the S-100 b gene on chromosome 21, neuroblastoma can be seen in Down’s syndrome. © Mattioli 1885.Öğe Primary papillary thyroid carcinoma in the thyroglossal cyst: Over eighty months follow up [Tiroglossal ductus kisti içerisinde primer tiroid papiller karsinomu ve seksen aydan fazla takibi](2011) Eryilmaz M.A.; Toy H.Papillary thyroid carcinoma within the thyroglossal duct cyst is a very rare finding and its presentation is like the benign cyst. A 22 years old female patient with a midline neck mass was initially diagnosed thyroglossal duct cyst and underwent Sistrunks procedure and upon histopathologic examination she was diagnosed papillary thyroid carcinoma within the thyroglossal cyst with regional lymph node metastasis. Than she sent to radioactive iodine ablation treatment after the thyroid gland evaluation and she was followed up over eighty months free of disease. Sistrunk procedure is usually treatment of choice for the thyroglossal duct cyst, but we could rarely find malignant thyroid carcinoma within the cyst. Than we should reevaluate the thyroid gland and if there is a positive finding we should add some additional treatment like radioactive iodine ablation, total thyroidectomy, and neck dissection.
