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    Effect of overweight and obesity on the left ventricular systolic and diastolic functions in patients with acute myocardial infarction
    (CANADIAN SOC CLINICAL INVESTIGATION, 2012) Poyraz, Fatih; Turfan, Murat; Kocaman, Sinan A.; Yazici, Huseyin U.; Sen, Nihat; Tulmac, Murat; Vatankulu, Mehmet A.
    Purpose: The purpose of this study was to evaluate whether a association exits among overweight and obesity and left ventricular systolic and diastolic functions in patients admitted with first ST-elevation myocardial infarction (STEMI). Methods: The present study was performed on 451 consecutive patients diagnosed with first STEMI (376 men, 75 women; mean age 56.1 +/- 10.8 years). The patients were classified into three groups based on their body mass index (BMI) as normal weight (BMI < 25 kg/m2), overweight (BMI: 25-29.9 kg/m2) and obese (BMI>30 kg/m2). Echocardiographic features were evaluated and compared among the three groups. Results: Mitral annulus E velocities were higher in obese individuals than normal weight group (p < 0.01). In contrast, mitral A velocities were lower (p = 0.03); consequently, E\A and E'\A' ratios were lower (both p = 0.01) in the obese group with respect to normal weight group. When the correction of entire variations existing among the groups were performed using multivariate linear regressions analyses, it turned out that BMI was independently associated with E/A (beta = -0.19, p = 0.044) and with E'/A' (beta = -0.016, p=0.021). Ejection fraction, wall motion score index and myocardial S velocities were comparable among the study groups (p > 0.05). Conclusion: These results suggest that while obesity has no adverse effect on the left ventricular systolic function, it has unfavorable consequences on the left ventricular diastolic function in the patients with first STEMI. In contrast, no unfavorable effects of overweight on the left ventricular systolic and diastolic function were detected.
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    The Relationship Between Admission Hemoglobin Level and and Left Ventricular Systolic Functions in Patients With First ST-segment Elevated Myocardial Infarction
    (2010) Şen, Nihat; Yazıcı, Hüseyin Uğur; Tavil, Yusuf; Poyraz, Fatih; Turfan, Murat; Aygül, Nazif; Vatankulu, Mehmet Akif; Özdoğru, İbrahim; Abacı, Adnan
    Objectives: The goal of this study was to evaluate the relationship between admission hemoglobin levels and left ventricular systolic functions in patients admitted with first ST-segment elevated myocardial infarction (STEMI). Study design: The study was conducted prospectively in three centers in 483 consecutive patients (402 men, 81 women; mean age 56.5±11.2 years; range 24 to 74 years) with first STEMI. All patients were evaluated by echocardiography after a mean of 2.4 days of admission. Evaluation of left ventricular systolic functions included measurements of ejection fraction (EF), wall motion score index (WMSI), and tissue Doppler S wave velocities at four different localizations (anterior, inferior, lateral, posterior septum). Hemoglobin levels were measured within one hour of admission. Anemia was defined according to the World Health Organization criteria (hemoglobin <13.0 g/dl in men and <12.0 g/dl in women). Echocardiographic characteristics of the patients with and without anemia were compared. Results: Anemia was detected in 67 patients (13.9%). There were no significant differences between patients with and without anemia with respect to left ventricular end-systolic and end-diastolic diameters, wall thickness, WMSI, and EF. The mean EF in the anemic group (47.5%) was lower than that of the patients without anemia (48.5%), but this difference was not significant. All Sm velocities were lower in the anemic group, but only septal mitral annular Sm velocity reached statistical significance (p0.048). There was no correlation between hemoglobin levels and EF (r0.027, p0.55). Conclusion: Our findings suggest that mild to moderate anemia has no deleterious effect on systolic function in patients with first STEMI.