Yazar "Uyaroglu, Aysen" seçeneğine göre listele

Listeleniyor 1 - 2 / 2
  • Küçük Resim Yok
    Öğe
    Effect of Acticoat (R) and Cutinova Hydro (R) on wound healing
    (WILEY-BLACKWELL, 2013) Arican, Mustafa; Hatipoglu, Fatih; Uyaroglu, Aysen; Ozdemir, Ozgur; Ozkan, Kadircan
    In this study, the effects of the wound-covering materials, Acticoat((R)) and Cutinova Hydro((R)), on wound healing have been studied in rabbit models with open and tissue-lost wounds with full-thickness flank excisions. Rabbits were used as subjects with three groups of four rabbits each, and trial periods of 7, 14 and 21{\uns}days. Four circular wounds, of 1.5 cm diameter were made two on the right (one of them control) and two on the left (one of them control) of the dorsal sides of the abdomen. Acticoat((R)) and Cutinova Hydro((R)) were applied on the wounds with suture for a period of 21 days and one each placed on the right and left sides as control with gauze. Biopsy specimens were taken from the animals at the end of the research period to check the length of the epithelium, epithelial thickness, size of wounds, wound granulation tissue formation and histopathological evaluation for clarity. The Acticoat((R)) group showed better healing and scar formation compared to the Cutinova Hydro((R)) group by macroscopic examination. Epithelial wound length and clarity in terms of statistical difference occurred on day 21 (P <0.05); while the length of the wound epithelium decreased patency, epithelial thickness on days similar to 7, 14 and 21, showed no statistical differences (P >0.05). As a result, the Acticoat((R)) wound dressing was determined as a more reliable for the early wound healing. This study has shown the short-term clinical benefits of hydroactive, polyurethane dressings in the management of acute wounds. However, longer periods of wound healing procedure should be planned for reliable and safe results of wound dressing. It has also been concluded that microbiological analyses should be included for more robust and reliable comparisons.
  • Küçük Resim Yok
    Öğe
    Effect of Asiaticoside, Collagenase, and Alpha-chymotrypsin on Wound Healing in Rabbits
    (H M P COMMUNICATIONS, 2016) Ozdemir, Ozgur; Ozkan, Kadircan; Hatipoglu, Fatih; Uyaroglu, Aysen; Arican, Mustafa
    Wound dressing materials such as asiaticoside, collagenase, and alpha-chymotrypsin are often used for effective wound healing activity. Objectives.' In this study; the effects of asiaticoside,, collagenase, and alpha-chymotrypsin were studied in rabbit models with open wounds with tissue loss and with full-thickness flank excisions for a period of 21 days, Materials and Methods. Three groups of 4 rabbits were examined during trial periods of 7, 14, and 21 days. Four circular wounds measuring 1.5 cm in diameter were made on the dorsal sides of the animals: 2 on the right and 2 the left. Asiaticoside, collagenase, and alpha-chymotrypsin were applied to wounds daily for a period of 7, 14, and 21 days, while 1 gauzed wound served as the control. All biopsy specimens were histopathologically evaluated for recovery. On day 7, microscopic review showed no differences in wound healing between groups. Results. By day 14, alpha-chyrnotrypsin showed the quickest reepithelialization (P<0.05); and by day 21 asiaticoside and collagenase (P<0.01) showed effective recovery, due to the completion of wound healing for all animals in both groups. Conclusion. Alpha-chymotrypsin is more effective than the other 2 groups for only 14 days. The effectiveness of asiaticoside and collagenase-displayed a more rapid improvement in comparison to alpha-chymotrypsin for healing open wounds with tissue loss for a period of 21 days.