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    Antibacterial, cytotoxicity, and phytotoxicity profiles of three medicinal plants collected from Pakistan
    (Marmara University, 2017) Rauf, Abdur; Uysal, Sengul; Ben Hadda, Taibi; Siddiqui, Bina S.; Khan, Haroon; Khan, Muhammad Atif; Ijaz, Muhammad; Mubarak, Mohammad S.; Bawazeer,Saud; Izneid,Tareq Abu; Khan, Ajmal; Farooq,Umar
    The purpose of present research was to examine the antibacterial, cytotoxic, and phytotoxic profiles of three important Pakistani medicinal plants viz., Teucrium stocksianum, Chenopodium botrys, and Micromeria biflora. The antibacterial, cytotoxicity, and phytotoxicity activities of samples extracted from these plants were evaluated by a modified agar well-diffusion method, brine shrimps cytotoxic assay, and Lemna acquinoctialisbased phytotoxic assay, respectively. Results revealed marked susceptibility of both the crude extracts and the aqueous fractions of these plants against K. pneumonia and B. subtilis. Methanolic extracts and aqueous fractions exhibited significant cytotoxicity in a concentration-dependent manner. Similarly, an outstanding phytotoxic effect was observed for the extracts/ fractions. Accordingly, the extracts and fractions of the aforementioned plants possess potential antibacterial, cytotoxic, and phytotoxic effects which could be useful in the search and development of new pharmaceutical agents. © 2017, Marmara University. All rights reserved.
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    Antibacterial, cytotoxicity, and phytotoxicity profiles of three medicinal plants collected from Pakistan
    (MARMARA UNIV, FAC PHARMACY, 2017) Rauf, Abdur; Uysal, Sengul; Ben Hadda, Taibi; Siddiqui, Bina S.; Khan, Haroon; Khan, Muhammad Atif; Ijaz, Muhammad; Mubarak, Mohammad S.; Bawazeer,Saud; Izneid,Tareq Abu; Khan, Ajmal; Farooq,Umar
    The purpose of present research was to examine the antibacterial, cytotoxic, and phytotoxic profiles of three important Pakistani medicinal plants viz., Teucrium stocksianum, Chenopodium botrys, and Micromeria biflora. The antibacterial, cytotoxicity, and phytotoxicity activities of samples extracted from these plants were evaluated by a modified agar well-diffusion method, brine shrimps cytotoxic assay, and Lemna acquinoctialis-based phytotoxic assay, respectively. Results revealed marked susceptibility of both the crude extracts and the aqueous fractions of these plants against K. pneumonia and B. subtilis. Methanolic extracts and aqueous fractions exhibited significant cytotoxicity in a concentration-dependent manner. Similarly, an outstanding phytotoxic effect was observed for the extracts/fractions. Accordingly, the extracts and fractions of the aforementioned plants possess potential antibacterial, cytotoxic, and phytotoxic effects which could be useful in the search and development of new pharmaceutical agents.
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    A comparative study of three drying methods on the phenolic profile and biological activities of Salvia absconditiflora
    (SPRINGER, 2019) Uysal, Sengul
    Drying method is one of the most important steps in the preparation of plant materials for phytochemical analysis and biological evaluation. In this sense, this research endeavoured to evaluate the effects three drying methods (oven, freeze, and shade drying) on phytochemical component, antioxidant, and enzyme inhibitory effects of Salvia absconditiflora Greuter & Burdet. Antioxidant activities were screened by phosphomolybdenum, DPPH, ABTS, FRAP, CUPRAC, and metal chelating activity. Enzyme inhibitory effects were assessed against cholinesterases (AChE, BChE), tyrosinase, -amylase, and -glucosidase. Drying methods were found to affect the chemical component and biological properties. Shade drying showed the highest TPC (99.33mgGAE/g) and TFC (46.88mgRE/g) followed by oven (58.15mgGAE/g for TPC, 40.65 for TFC), and freeze drying (43.73mgGAE/g for TPC, 36.68mgRE/g for TFC). The main phenolic compound characterized by HPLC was rosmarinic acid, which was observed to be highest following shade drying. Shade drying contained highest total bioactive compounds and exhibited the strongest antioxidant properties. The enzyme inhibitory effects of S. absconditiflora performed using different depends were dependent on the drying methods. Our results tend to suggest that shade drying was most suitable for S. absconditiflora because of possessing the highest rosmarinic acid and biological properties.
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    In vivo and in silico sedative-hypnotic like activity of 7-methyljuglone isolated from Diospyros lotus L.
    (ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER, 2017) Rauf, Abdur; Uysal, Sengul; Ben Hadda, Taibi; Uddin, Ghias; Nawaz, Muhammad Asif; Khan, Haroon; Siddiqui, Bina S.
    Diospyros lotus L. possesses different therapeutic activities such as antioxidant, anti-proliferative, antimicrobial and sedative. However, no studies on the sedative-hypnotic activity of 7-methyljuglone are reported. In the present study, we have evaluated in vivo the anxiolytic-hypnotic like effects of 7-methyljuglone in mice with open field and phenobarbitone-induced sleeping time tests. We have also assessed in silico the involvement of GABA(A), GABA(B) and 5HT1 neurotransmission in its mechanism of action. The intraperitoneal administration of 7-methyljuglone (2.5-10 mg/kg) reduce significantly the number of crossed lines in mice open field test and concomitantly it shown a significant activity in term of onset of sleeping time and also in its duration. Moreover, 7-methyljuglone demonstrated in silico an interesting interaction with GABAA but not GABAB and 5HT1binding sites. All of these results, taken together, 7-methyljuglone may be an innovative candidate for designing new pharmaceutical and therapeutic applications. (C) 2017 Elsevier Masson SAS. All rights reserved.