Yazar "Vatansev H." seçeneğine göre listele

Listeleniyor 1 - 3 / 3
  • Küçük Resim Yok
    Öğe
    Atypical middle lobe and lingula involvement in kerosene pneumonitis [2]
    (2004) Kanat F.; Vatansev H.; Ozer F.; Imecik O.
    [Abstract not Available]
  • Küçük Resim Yok
    Öğe
    The clinical value of interleukins-8, -10, and -17 in idiopathic granulomatous mastitis
    (Springer, 2020) Koksal H.; Vatansev H.; Artac H.; Kadoglou N.
    Introduction: Idiopathic granulomatous mastitis (IGM) is a rare, chronic inflammatory benign breast disease. Although the etiology of this disease is unknown, it has been suggested that hormonal disorders, autoimmunity, smoking, and ?1-antitrypsin deficiency may play a role in the etiopathogenesis. The aim is to investigate the changes in cytokine profiles including interleukin (IL)-4, -8, -10, -17, and tumor necrosis factor (TNF)-alpha in patients with IGM. Methods: Forty-seven patients with pathologically diagnosed IGM and 30 healthy women were included. The cytokines including IL-4, -8, 10, -17, and TNF-alpha were measured by human enzyme-linked immunosorbent assay. Results: The IL-8, IL-10, and IL-17 levels were higher in IGM patients than control group (p =.002; p =.008; and p =.018, respectively). The IL-8 levels of patients with active lesions and in remission were statistically higher than the control group (p =.027 and p =.015, respectively). IL-10 levels of patients in remission were higher than the control group (p =.024). There was no difference in IL-4 and TNF-? levels between all groups. Conclusion: These results showed that proinflammatory cytokines including IL-8 and IL-17 have role in pathogenesis of IGM. However, the increased levels of IL-10 in especially patients in remission suggest that it reduces the release of proinflamatory cytokines as well as suppressing their function and activation for controlling IGM. Although IGM is thought to be a surgical disease, these cytokine changes indicate the presence of serious immune dysregulation. This suggests that in the treatment of IGM, treatment needs to evolve from surgery to medical treatment.Key points The IL-8, IL-10, and IL-17 levels were higher in IGM patients than in control group. The IL-8 levels of both patients with active lesions and in remission were high. There was no difference in IL-4 and TNF-? levels between all groups. © 2020, International League of Associations for Rheumatology (ILAR).
  • Küçük Resim Yok
    Öğe
    The role of prohepcidin and hepcidin in anemia associated with systemic lupus erythematosus
    (2011) Dagli M.; Yilmaz S.; Sivrikaya A.; Cehk G.; Vatansev H.
    The aim of the study is to investigate the role of circulating prohepcidin and hepcidin, a homeostatic regulator of iron metabolism and a mediator of inflammation, in anemia associated with systemic lupus erythematosus(SLE) and differential diagnosis of iron deficiency anemia (IDA). Fourty patients with SLE (12 with anemia and 28 without anemia), 30 patients with IDA and 20 healthy adults were studied. Serum prohepcidin and hepcidin levels were analyzed by using a commercially available kits (DRG prohepcidin and hepcidin ELISA kits). Serum prohepcidin and hepcidin levels in patients with SLE were significantly higher than those with IDA and healthy group. In the group with IDA and SLE positive correlation was determined between the values of serum prohepcidin, hepcidin, Hb, TIBC and ferritin. Serum prohepcidin and hepcidin levels are not closely associated with disease activity in patients with SLE, but might play a role in the pathobiology of chronic disease anemia associated with SLE. © IDOSI Publications, 2011.