The role of prohepcidin and hepcidin in anemia associated with systemic lupus erythematosus
Küçük Resim Yok
Tarih
2011
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
The aim of the study is to investigate the role of circulating prohepcidin and hepcidin, a homeostatic regulator of iron metabolism and a mediator of inflammation, in anemia associated with systemic lupus erythematosus(SLE) and differential diagnosis of iron deficiency anemia (IDA). Fourty patients with SLE (12 with anemia and 28 without anemia), 30 patients with IDA and 20 healthy adults were studied. Serum prohepcidin and hepcidin levels were analyzed by using a commercially available kits (DRG prohepcidin and hepcidin ELISA kits). Serum prohepcidin and hepcidin levels in patients with SLE were significantly higher than those with IDA and healthy group. In the group with IDA and SLE positive correlation was determined between the values of serum prohepcidin, hepcidin, Hb, TIBC and ferritin. Serum prohepcidin and hepcidin levels are not closely associated with disease activity in patients with SLE, but might play a role in the pathobiology of chronic disease anemia associated with SLE. © IDOSI Publications, 2011.
Açıklama
Anahtar Kelimeler
Anemia, Hepcidin, Prohepcidin, Systemic lupus erythematosus
Kaynak
World Applied Sciences Journal
WoS Q Değeri
Scopus Q Değeri
N/A
Cilt
13
Sayı
9