The role of prohepcidin and hepcidin in anemia associated with systemic lupus erythematosus

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dc.contributor.authorDagli M.
dc.contributor.authorYilmaz S.
dc.contributor.authorSivrikaya A.
dc.contributor.authorCehk G.
dc.contributor.authorVatansev H.
dc.date.accessioned2020-03-26T18:22:23Z
dc.date.available2020-03-26T18:22:23Z
dc.date.issued2011
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractThe aim of the study is to investigate the role of circulating prohepcidin and hepcidin, a homeostatic regulator of iron metabolism and a mediator of inflammation, in anemia associated with systemic lupus erythematosus(SLE) and differential diagnosis of iron deficiency anemia (IDA). Fourty patients with SLE (12 with anemia and 28 without anemia), 30 patients with IDA and 20 healthy adults were studied. Serum prohepcidin and hepcidin levels were analyzed by using a commercially available kits (DRG prohepcidin and hepcidin ELISA kits). Serum prohepcidin and hepcidin levels in patients with SLE were significantly higher than those with IDA and healthy group. In the group with IDA and SLE positive correlation was determined between the values of serum prohepcidin, hepcidin, Hb, TIBC and ferritin. Serum prohepcidin and hepcidin levels are not closely associated with disease activity in patients with SLE, but might play a role in the pathobiology of chronic disease anemia associated with SLE. © IDOSI Publications, 2011.en_US
dc.identifier.endpage2036en_US
dc.identifier.issn1818-4952en_US
dc.identifier.issue9en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage2032en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12395/27310
dc.identifier.volume13en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.relation.ispartofWorld Applied Sciences Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectAnemiaen_US
dc.subjectHepcidinen_US
dc.subjectProhepcidinen_US
dc.subjectSystemic lupus erythematosusen_US
dc.titleThe role of prohepcidin and hepcidin in anemia associated with systemic lupus erythematosusen_US
dc.typeArticleen_US

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