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    Plasma essential fatty acid levels and ?-6/?-3 ratio in healthy people living in our region [Bölgemizde yaşayan sa?likli kişilerde plazma esansiyel ya? asidi düzeyleri ve ?-6/?-3 ya? asitleri orani]
    (2011) Yerlikaya F.H.; Mehmeto?lu I.; Sivrikaya A.
    Objective: Essential fatty acids are essential for survival of humans and other mammals, and they can not be synthesized in the body: hence, they have to be obtained by the diet. There are two types of essential fatty acids in the body, the omega-6 (?6) series derived from linoleic acid and the omega-3 (?3) series derived from linolenic acid. In this study we aimed to examine plasma essential fatty acid levels, omega-6/omega-3 (?6/?3) ratio and these fatty acids in the relationship between body mass index (BMI) and waist circumference in healty subjects living in our region. Material and Methods: This study was performed on 91 (31 male 60 female) healthy people living in the city of Konya aged 18-70 years. There was no complaints and symptoms of the healthy people. Fatty acid levels were measured by Gas chromatography-mass spectrometry technique. Results: There were no significant differences between plasma essential fatty acid levels of the male and female healthy subjects. There were significantly positive correlations between plasma ?-6 fatty acid levels with BMI and waist circumference in the female healty subjects. Plasma ?6/?3 ratio of healthy male and female subjects was found as follows: 20.35 ± 14.7 and 20.16 ± 13.5 respectively. Conclusion: Plasma ?6/?3 ratio of healthy people living in our region is much higher than the rate recommended by world health organization. Furhermore, in this study show there is positive associations between BMI and waist circumference with plasma ?-6 fatty acid levels. Trigger many diseases, including obesity, the high ?-6 fatty acid content in the diet should be limited. Copyright © 2011 by Türkiye Klinikleri.
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    Relationship between fetuin-A, inflammation, coronary artery calcification in hemodialysis and peritoneal dialysis patients
    (2012) Türkmen K.; Kayikçio?lu H.; Özbek O.; Gaipov A.; Yerlikaya F.H.; Toker A.; Tonbul H.Z.
    OBJECTIVE: Vascular calcification is commonly seen in patients with end-stage renal disease (ESRD). Fetuin-A has been found to be a vascular calcification inhibitor and its level is significantly low in ESRD patients. The aim of our study was to investigate the relation between coronary artery calcification, inflammation and fetuin-A levels in peritoneal dialysis (PD) and hemodialysis (HD) patients. MATERIAL and METHODS: 46 PD (M/F=28/18) and 34 (M/F=20/14) HD patients were included in the study. Coronary artery calcification scoring was made by multi slice computed tomography. PD and HD patients were divided into 2 groups according to their median CACS values Serum levels of fetuin-A, CRP, IL-6 and TNF-a are studied. RESULTS: There were no differences in demographic features of PD and HD patients. There was a correlation between CACS, advanced age, dialysis vintage and fetuin-A. We could not find any correlation between infiammatory markers and CACS. There was a statistically significant difference between fetuin-A and CACS groups. CONCLUSION: Age, duration of dialysis, fetuin-A levels were found to be related to CACS in PD and HD patients. Fetuin-A may play a role in increased mortality in this population via facilitating CACS.