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    En coup de sabre accompanied by pachydermoperiostosis: a case report
    (CLINICAL & EXPER RHEUMATOLOGY, 2007) Ozdemir, M.; Yildirim, S.; Mevlitoglu, I.
    Scleroderma en coup de sabre, a variant of localized scleroderma is a disorder characterized by fibrosis of connective tissue. We report a 21-year-old female with scleroderma en coup de sabre accompanied by pachydermoperiostosis. She was born to consanguineous parents and her older siser also had pachydermoperiostosis characterized by clubbing of the digits, enlargement of distal parts of the extremities. The two disorders were diagnosed by clinical examination, histological and x-ray findings. In contrast to scleroderma, pachydermoperiostosis is a hypertrophic process characterized by periosteal proliferation of the tubuler bones and hypertrophic skin changes. We discuss this interesting coexistence and review the literature.
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    The role of dental pulp cells in resorption of deciduous teeth
    (MOSBY-ELSEVIER, 2008) Yildirim, S.; Yapar, M.; Sermet, U.; Sener, K.; Kubar, A.
    Objective. To address the question whether dental pulp cells of exfoliating human deciduous teeth have some roles for controlling or regulating the root resorption via secreting key molecules (OPG, RANKL, CSF-1, TGF beta, MCP-1 and Cbfa-1) in osteoclastogenesis, we used a sensitive reverse transcriptase polymerase chain reaction (RT-PCR) method for detection of mRNA expressions for the cytokines listed. Study design. The dental pulps were retrieved from incisor and molar teeth in the late stage of shedding (n = 30) and from sound premolar teeth extracted for orthodontic reasons (control group; n = 30). The RT-PCR assays were used to identify targeted gene expression. Results. Of the cytokines examined, RANKL and CSF-1 expressions showed significantly higher occurrence in deciduous dental pulps than in permanent teeth pulpal tissues (P < .040). Conclusions. The findings may suggest an interactive role for pulp tissue cells in the physiologic root resorption process. The cells of dental pulp may have some cytokine-producing cells which mediate monocyte-macrophage lineage to form osteo/odontoclasts, and the RANKL/RANK system might be involved in human deciduous teeth resorption.
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    Use of aluminium hydroxide and calcium phosphate as delivery molecules for TGF-beta(1)
    (INDIAN VETERINARY JOURNAL, 2007) Ucan, U. S.; Yildirim, S.; Simsek, A.; Ortatatli, M.; Erganis, O.
    Transforming Growth Factor-beta(1) (TGF - beta(1))'s mitogenic activities have been documented to some extent in dentinogenesis and wound healing. However, TGF as a therapeutical agent has not been considered neither in veterinary nor in medical dentistry so far. In order to examine this, it is first necessary. to incorporate the cytokine to a slow delivery system and then to show its various effects on different types of cells. The present study was designed to evaluate the properties of two different adjuvants, aluminium hydroxide (AH) and calcium phosphate (CP), as delivery substances for recombinate human TGF-beta(1).