Yazar "Yildiz, Ramazan" seçeneğine göre listele
Listeleniyor 1 - 14 / 14
Sayfa Başına Sonuç
Sıralama seçenekleri
Öğe Babesia ovis infections: Detailed clinical and laboratory observations in the pre- and post-treatment periods of 97 field cases(ELSEVIER SCIENCE BV, 2013) Sevinc, Ferda; Sevinc, Mutlu; Ekici, Ozlem Derinbay; Yildiz, Ramazan; Isik, Nermin; Aydogdu, UgurOvine babesiosis, caused by Babesia ovis, is of major economic importance in Turkey. The changes in the blood profile of infected animals are informative about the course of infection. The aim of the present study was to evaluate the hematological and biochemical changes in the pre- and post-treatment periods of the natural B. ovis infections. The presence of the parasites was confirmed by microscopy and polymerase chain reaction (PCR) analysis. On the basis of the clinical and laboratory findings, the infections were categorized into different groups according to the degree of anemia and the level of parasitemia. All infected sheep were treated with imidocarb dipropionate (IMDP). The blood pictures in the pre- and post-treatment periods were compared. Pancytopenia occurred in animals with severe anemia and very high parasitemia, and bicytopenia in the other groups. The platelet count (PLT), plateletcrit (PCT) and mean platelet volume (MPV) returned to the normal ranges after treatment, except those in the group with severe anemia. In the biochemical profile, B. ovis infection caused an increase in blood urea nitrogen and total bilirubin, and these parameters returned to normal levels after treatment. The indirect fluorescein antibody test (IFAT) results showed that 38.1% of the cases raised specific antibodies during the period of infection, with titers ranging from 1/160 to 1/640. All of 45 animals re-examined after treatment were seropositive, with high titers that rose up to 1/5120. (C) 2012 Elsevier B.V. All rights reserved.Öğe Biological Subtypes and Survival Outcomes in Breast Cancer Patients with Brain Metastases (Study of the Anatolian Society of Medical Oncology)(KARGER, 2012) Kaplan, Muhammet Ali; Isikdogan, Abdurrahman; Koca, Dogan; Kucukoner, Mehmet; Gumusay, Ozge; Yildiz, Ramazan; Dayan, AdemBackground: The aim of this study is to determine the relationship between the survival outcomes and biological subtype in breast cancer patients with brain metastases. Methods: We retrospectively evaluated clinical data from 422 breast cancer patients with brain metastases between 2001 and 2011 from referral centers in Turkey. The study population was divided into four biological subtypes according to their hormone receptor status and HER2 expression. Results: Systemic treatment prolonged median overall survival (OS) after brain metastases in the entire group (14 vs. 3.2 months, p < 0.001). It also prolonged median OS after brain metastases in the triple negative (7.5 vs. 1.6 months, p = 0.010) and luminal A (14.3 vs. 7.1 months, p = 0.003) subgroups. The median OS for untreated patients, chemotherapy and/or hormonal therapy receiving patients, and chemotherapy and/or hormonal therapy plus targeted therapy receivers was 2, 5.8, and 17.7 months, respectively (p < 0.001), in the HER2-overexpressing subgroup. In the luminal B subgroup, it was 3.7, 5.3, and 15.4 months, respectively (p = 0.003). Conclusions: The use of systemic therapy improves OS after brain metastases in all biological subgroups. Targeted therapies also improve OS after brain metastases in HER2-positive patients. The combined use of targeted therapies and lapatinib are superior to single use and trastuzumab, respectively, in these patients. Copyright (C) 2012 S. Karger AG, BaselÖğe CARDIAC BIOMARKERS IN PREMATURE CALVES WITH RESPIRATORY DISTRESS SYNDROME(AKADEMIAI KIADO RT, 2016) Aydogdu, Ugur; Yildiz, Ramazan; Guzelbektes, Hasan; Coskun, Alparslan; Sen, IsmailThe aim of this study was to determine the clinical relevance of cardiac biomarkers [troponin I and T, creatine kinase-MB fraction (CK-MB) and lactate dehydrogenase (LDH)] in premature calves with respiratory distress syndrome. Seventy premature calves were admitted to the clinic within 24 h after birth. Respiratory distress syndrome was diagnosed in premature calves by clinical examination and venous blood gas analysis. Ten healthy calves, aged 5 days, were used as control. Cardiac troponin I and T were analysed using ELISA and ELFA, respectively. Serum CK-MB and LDH were also analysed in an automatic analyser. The calves had low venous pH, pO(2), O-2 saturation and high pCO(2) values consistent with dyspnoea, hypoxaemia, and inadequate oxygen delivery. Mean serum troponin I, troponin T, CK-MB and LDH levels were increased in the premature calves compared to the control group. In conclusion, the results in this study demonstrated that serum CK-MB, troponin I and troponin T concentrations could be used for evaluating myocardial injury in premature calves with respiratory distress syndrome.Öğe Clinical outcomes in patients who received lapatinib plus capecitabine combination therapy for HER2-positive breast cancer with brain metastasis and a comparison of survival with those who received trastuzumab-based therapy: a study by the Anatolian Society of Medical Oncology(SPRINGER JAPAN KK, 2014) Kaplan, Muhammet Ali; Isikdogan, Abdurrahman; Koca, Dogan; Kucukoner, Mehmet; Gumusay, Ozge; Yildiz, Ramazan; Dayan, AdemIn this study, we investigated the effect of lapatinib plus capecitabine treatment in HER2-positive breast cancer patients with brain metastasis. Of 405 metastatic breast cancer patients with brain metastases at referral centers in Turkey, 46 were treated with lapatinib plus capecitabine only after the development of brain metastasis. Patients who only received trastuzumab-based therapy after the development of brain metastases were accepted as the historic control group for survival analyses (n = 65). Patients who received both drugs consecutively or sequentially were excluded from the analyses (n = 34). Median age among 46 patients who received lapatinib plus capecitabine therapy was 45 years (27-76), and median time for development of brain metastases was 11.9 months (0-69 months). Twenty-six out of 38 patients who received lapatinib plus capecitabine and had extracranial metastasis showed partial response or stable diseases (68.4 %). Grade 3-4 toxicity was observed in eight patients (17.3 %). Median overall survival (OS) in patients treated with lapatinib plus capecitabine was significantly increased compared to that in patients treated with trastuzumab-based therapy (19.1 vs. 12 months, respectively, p = 0.039). The incidence of cerebral death was slightly decreased in patients who received lapatinib plus capecitabine compared to those who received trastuzumab-based therapy (32 vs. 43.4 %, p = 0.332). In the multivariate analysis, lapatinib plus capecitabine therapy remained an independent positive predictor for survival [odds ratio (OR), 0.57; p = 0.02]. Although this retrospective multicenter study had several limitations, the results suggest that undergoing lapatinib plus capecitabine therapy after the diagnosis of brain metastasis may further improve survival compared to undergoing only trastuzumab-based therapy.Öğe Comparison of the Effectiveness of Halofuginone Lactate and Paromomycin in the Treatment of Calves Naturally Infected with Cryptosporidium parvum(UNIV FED RIO GRANDE DO SUL, 2018) Aydogdu, Ugur; Isik, Nermin; Ekici, Ozlem Derinbay; Yildiz, Ramazan; Sen, Ismail; Coskun, AlparslanBackground: Cryptosporidiosis is one of the most important problems among neonatal ruminants. Cryptosporidium parvum is the agent causing the disease. Cryptosporidium infection, responsible for diarrhea, dehydration, weight loss and death in neonatal ruminants, leads to significant economic losses for producers. In calves naturally or experimentally infected with cryptosporidiosis, many agents have been reported to have therapeutic and protective effects. The objective of this study was to compare the effectiveness of halofuginone lactate and paromomycin in the treatment of calves naturally infected with Cryptosporidium parvum. Materials, Methods & Results: Twenty calves between 7 and 20 days of age and naturally infected were included in the study. There were two different treatment groups in the study. The first group of calves were administered 100 mu g/kg/day halofuginone lactate for 7 days and the second group of calves were administered 100 mg/kg/day paromomycin for 7 days. In addition, antibiotic and vitamin C were applied to all calves. Jugular venous blood samples were obtained pre-treatment and on the 7th day after the treatment. Routine clinical examinations of the calves were performed on days 0, 1, 3, 5 and 7 and rectal stool samples were collected for the detection of Cryptosporidium oocysts. Severe diarrhea, dehydration, depression and weight loss were observed in calves in both treatment groups. A significant decrease (P < 0.05) was observed for both groups in oocyst count on days 3, 5 and 7 compared to days 0 and 1. Improvements in blood parameters, stool characters and clinical scoring of both groups were observed in post-treatment. Discussion: Many pharmaceuticals or compounds have been tested for animal with cryptosporidiosis and only very few of them have shown a partial protective activity in ruminants when used prophylactically. Halofuginone lactate and paromomycin are commonly recommended as both therapeutic and protective agents. However, the effectiveness of the two therapeutic agents in natural infections has not been compared and, in the meantime, recommendations for a rational use are also not sufficiently documented in calves with cryptosporidiosis. Paromomycin is an aminoglycoside antibiotic used to control C. parvum infection in animals. Paromomycin reduces oocyst shedding and the number of days with diarrhea in experimentally infected calves when used prophylactically. Halofuginone lactate is a synthetic quinazolinone with cryptosporidial activity in the merozoite and sporozoite stages of C. parvum. It is recommended for both therapeutic and prophylactic use in cryptosporidiosis. In this study, although paromomycin (100 mg/kg/day for 7 days) and halofuginone lactate (100 mu g/kg/day for 7 days) led to a decrease in oocyst shedding from day 1, a statistically significant decrease (P < 0.05) was observed from day 3. The results of this study show that the decrease in oocyst shedding in both treatment groups, improvements in clinical findings and recoveries in hematologic, blood gas and serum biochemistry values are similar. Even though these drugs do not eliminate the infection, they decrease both the severity of diarrhea and contribute to recovery. In conclusion, the results of this study indicated that halofuginone lactate and paromomycin were effective in the treatment of calves naturally infected with cryptosporidiosis. Therefore, we recommend that both drugs should be used in the treatment of calves naturally infected with Cryptosporidium parvum.Öğe Ectopic Reticulum in a Cow(UNIV AGRICULTURE, FAC VETERINARY SCIENCE, 2016) Altan, Semih; Koc, Yilmaz; Alkan, Fahrettin; Erol, Muharrem; Yildiz, RamazanA two years-old Holstein cow with poor appetite, reduced milk production, and partial defecation was evaluated in the present case report. After routine laboratory and clinical examinations, the animal further received ultrasound examination and then a right fossa paralumbal exploratory laparotomy was performed to the cow. The cow was diagnosed with ectopic reticulum on the laparotomy. After the content of the reticulum was removed, liquid paraffin was administered into the reticulum and its wall and abdominal wall was sutured as routinely. The prognosis of the animal deteriorated gradually following to the laparotomy and it was slaughtered by its owner. This is the first report showing the presence of an ectopic reticulum in a cow. (C) 2016 PVJ. All rights reservedÖğe The effect of 12 successive blood passages on the virulence of Babesia ovis in splenectomized lambs: A preliminary study(ELSEVIER, 2014) Sevinc, Ferda; Sevinc, Mutlu; Koc, Yilmaz; Alkan, Fahrettin; Ekici, Ozlem Derinbay; Yildiz, Ramazan; Isik, NerminBabesia ovis, the primary causative agent of ovine babesiosis, is a tick-borne hemoprotozoan parasite and causes serious losses in small ruminant livestock in tropical and subtropical regions. The current control of ovine babesiosis has been base on chemotherapy and limited tick control measures. Attenuated parasites which are valuable sources of live vaccines have been used to prevent babesiosis in cattle. There is a necessity to the studies about prevention of the disease by means of immunoprophylaxis in sheep. For this purpose, this study was planned to obtain the attenuated derivatives of a virulent B. ovis strain by successive blood passages in splenectomized lambs. A total of seventeen, six-month-old lambs, 13 of which splenectomized, 4 of which spleen intact lambs, known to be negative for the presence of hemoparasites and anti-B. ovis antibodies were used. The splenectomized lambs were used for passaging the virulent B. ovis field strain. Four intact lambs divided into two groups were used to evaluate the pathogenicity of the virulent strain and twelfth passage strain of B. ovis. Blood collected from a clinically evident case of babesiosis in the field was inoculated intravenously into the first splenectomized lamb, and then the acute clinical disease was occurred. The same process was successively applied to the rest of 12 splenectomized lambs to have the attenuated B. ovis strain. The clinical, microscopic and hematological changes after inoculation were recorded in each passage of the lambs. All of the passage lambs were exhibited the severe symptoms of the disease from the 2nd day of inoculation. The same treatment protocol including vitamin B12 and the anti-babesial drug imidocarb dipropionate (IMDP) was applied to all splenectomized lambs on the fourth or fifth day of the inoculation. Although the symptoms of the disease were less severe than those of splenectomized lambs; two intact lambs infected with the virulent strain and two intact lambs infected with the twelfth passage blood were also showed the clinical and hematological findings of the disease on the 2nd and 3rd day after inoculation. Infection-related symptoms in all intact lambs disappeared spontaneously from the 6th day of inoculation without the application of any drug. The results of the study showed that there was no change on the virulence of B. ovis through the 12 successive blood passages. Therefore, the further passages or alternative attenuation methods may be necessary to attenuate the virulent strain of B. ovis. (C) 2013 Elsevier B.V. All rights reserved.Öğe The efficacy and safety of first-line and salvage therapies with bevacizumab combination chemotherapy regimens in metastatic colorectal cancer: A retrospective ASMO experience.(AMER SOC CLINICAL ONCOLOGY, 2013) Yildiz, Ramazan; Buyukberber, Suleyman; Koca, Dogan; Korai, Lokman; Ciltas, Aydin; Unal, Olcun Umit; Gumus, Mahmut[Abstract not Available]Öğe Evaluation of acute phase proteins, some cytokines and hemostatic parameters in dogs with sepsis(KAFKAS UNIV, VETERINER FAKULTESI DERGISI, 2015) Ok, Mahmut; Er, Cenk; Yildiz, Ramazan; Col, Ramazan; Aydogdu, Ugur; Sen, Ismail; Guzelbektes, HasanThe aim of this study was to evaluate the alterations in acute phase proteins, cytokines and hemostatic parameters in dogs with sepsis and to determine the importance of these parameters in diagnosis of the sepsis. Thirty dogs with sepsis and 9 healthy dogs were used in this study. Anorexia, depression, lethargy, hyperthermia, tachycardia, tachypnea, congestion in the mucosal membranes, prolonged capillary refill time, and leukocytosis or leucopenia were identified in the dogs with sepsis. The serum interleukin-1 beta (IL-1 beta), tumor necrosis factor alpha (TNF-alpha), interferon gamma (INF-gamma), C-reactive protein (CRP), serum amyloid A (SAA), prothrombin time (PT), activated partial thromboplastin time (aPTT), antithrombin III (AT III), fibrinogen, protein C (PC), and D-dimer levels were measured in all dogs. We found that the serum IL-1 beta, TNF-alpha, INF-gamma, CRP and SAA concentrations were significantly elevated in dogs with sepsis as compared with healthy controls. In addition, the plasma PT and APTT levels were notably prolonged, the plasma fibrinogen, D-dimers and protein C concentrations were significantly increased. However, the antithrombin III activity was significantly decreased in the dogs with sepsis. In conclusion, the results of this study indicate that the SAA, IL-1 beta and TNF-alpha parameters play important roles in the inflammatory process in dogs with sepsis. The hemostatic abnormalities observed in dogs with sepsis may be due to the development of disseminated intravascular coagulation (DIC).Öğe The importance of concentrations of sorbitol dehydrogenase and glutamate dehydrogenase and b-mode ultrasonographic examination in the diagnosis of hepatic lipidosis in dairy cows(KAFKAS UNIV, VETERINER FAKULTESI DERGISI, 2013) Ok, Mahmut; Sen, Ismail; Guzelbektes, Hasan; Boydak, Murat; Er, Cenk; Aydogdu, Ugur; Yildiz, RamazanThe aim of this study is to determine the importance of B-mode ultrasonography in the diagnosis of hepatic lipidosis in dairy cows and compare this mode of diagnosis with both the histologic examination of liver biopsy samples and investigation of some biochemical parameters associated with hepatic lipidosis. 15 Holstein cows with moderate hepatic lipidosis and 15 cows with severe hepatic lipidosis and 6 healtyh cows were used as a metarilas. Blood samples were obtained from all cows and analyzed. Liver samples were obtained by biopsy in cattle. The ultrasonographic examination of liver was performed on animal. Serum glutamate dehydrogenase (GDH) and aspartate amino transferase (AST) concentrations were increased in cows with moderate hepatic lipidosis. Serum sorbitol dehydrogenase (SDH), GDH, and AST concentrations were increased in cows with severe hepatic lipidosis. Ultrasonographic examination revealed an increase in diffuse echogenicity of the liver in cows with moderate and severe hepatic lipidosis cows, but the increase was little in moderate hepatic lipidosis. Both serum GDH and SDH levels were found to be increased in severe hepatic lipidosis. However, only the serum GDH level was elevated in moderate hepatic lipidosis. Therefore, both ultrasonographic examination and measurement of specific liver enzymes seem to be beneficial in the diagnosis of hepatic lipidosis.Öğe Intravenous pharmacokinetics of moxifloxacin following simultaneous administration with flunixin meglumine or diclofenac in sheep(WILEY, 2019) Altan, Feray; Corum, Orhan; Yildiz, Ramazan; Faki, Hatice Eser; Ider, Merve; Ok, Mahmut; Uney, KamilIn this study, the pharmacokinetics of moxifloxacin (5 mg/kg) was determined following a single intravenous administration of moxifloxacin alone and co-administration with diclofenac (2.5 mg/kg) or flunixin meglumine (2.2 mg/kg) in sheep. Six healthy Akkaraman sheep (2 +/- 0.3 years and 53.5 +/- 5 kg of body weight) were used. A longitudinal design with a 15-day washout period was used in three periods. In the first period, moxifloxacin was administered by an intravenous (IV) injection. In the second and third periods, moxifloxacin was co-administered with IV administration of diclofenac and flunixin meglumine, respectively. The plasma concentration of moxifloxacin was assayed by high-performance liquid chromatography. The pharmacokinetic parameters were calculated using a two-compartment open pharmacokinetic model. Following IV administration of moxifloxacin alone, the mean elimination half-life (t(1/2 beta)), total body clearance (Cl-T), volume of distribution at steady state (V-dss) and area under the curve (AUC) of moxifloxacin were 2.27 hr, 0.56 L h(-1) kg(-1), 1.66 L/kg and 8.91 hr*mu g/ml, respectively. While diclofenac and flunixin meglumine significantly increased the t(1/2 beta) and AUC of moxifloxacin, they significantly reduced the Cl-T and V-dss. These results suggest that anti-inflammatory drugs could increase the therapeutic efficacy of moxifloxacin by altering its pharmacokinetics.Öğe Pharmacokinetics of pentoxifylline and its 5-hydroxyhexyl metabolite following intravenous administration in cattle(SPRINGER, 2019) Uney, Kamil; Tras, Bunyamin; Corum, Orhan; Yildiz, Ramazan; Maden, MehmetThis study investigated the pharmacokinetics of pentoxifylline (PTX) and its 5-hydroxyhexyl metabolite (M-I) after single-dose intravenous (IV) administration (10mg/kg) of PTX in six healthy cattle. The safety of PTX was evaluated by clinical observation and biochemical analysis. Plasma concentrations of PTX and M-I were simultaneously determined by reverse-phase high performance liquid chromatography. Pharmacokinetic parameters were calculated using non-compartmental methods. Salivation and discomfort were observed for 2h following the drug administration. Serum direct bilirubin, total bilirubin, and phosphorus levels at 24h following the drug administration were significantly different from the control values (0h) (P<0.05). Pharmacokinetic variables of PTX were characterized by a short terminal elimination half-life (1.05 +/- 0.19h), a large volume of distribution (6.30 +/- 1.76L/kg), and high total body clearance (5.31 +/- 1.27L/h/kg). The mean ratio between the area under the concentration-time curves of M-I and PTX was 1.34. These results indicate that single-dose administration of PTX at 10mg/kg IV in cattle resulted in therapeutic concentrations similar to those observed in humans and horse. However, further studies are necessary to determine the safety and pharmacokinetics following repeated administrations of PTX.Öğe Plasma metabolomics in calves with acute bronchopneumonia(SPRINGER, 2016) Basoglu, Abdullah; Baspinar, Nuri; Tenori, Leonardo; Vignoli, Alessia; Yildiz, RamazanBackground Bovine respiratory disease is one of the main health issues in dairy calves. Inflammatory lung diseases are highly complex with respect to pathogenesis and relationships between inflammation, clinical disease and response to treatment. Metabolomics may offer the potential to identify biomarkers that define calf bronchopneumonia in terms of combined clinical, physiological and patho-biological abnormalities. While metabolomic studies are often encountered in childhood pneumonia, there is no knowledge related to the same approach to calf pneumonia. Objective The aim of this first study was to reveal the new potential biomarkers for acute calf bronchopneumonia by single proton (H-1) Nuclear magnetic resonance (NMR) based quantitative metabolomics. Methods Fifty dairy calves with acute bronchopneumonia presented for treatment to the teaching hospital, and ten healthy dairy calves belonging the teaching farm were used. Laboratory (hematological: complete blood count and blood gas analysis, and biochemical analysis related to health profile) were performed. NMR spectra of the all samples (50 diseased + 10 healthy water soluble extracts, 50 diseased + 10 healthy lipid extracts) were acquired using a standard Nuclear Overhauser Effect Spectroscopy pulse sequence. Results NMR based metabolomics analysis showed that calves suffering from bronchopneumonia and healthy calves have two different and distinguishable metabolic fingerprints using both water soluble and lipid extracts. Alterations in metabolites, increases in 2-methyl glutarate, phenylalanine, phosphatidylcholine, and decreases in ethanol, dimethylsulfone, propionate, acetate, allantoin, free cholesterol, cholesterol (-C18), were meaningful for pathogenic mechanisms of calf bronchopneumonia. Conclusion The NMR based metabolomics may contribute to better understanding bronchopneumonia in calves.Öğe Ultrasonographic finding in anterior displacement of abomasum in a cow(KAFKAS UNIV, VETERINER FAKULTESI DERGISI, 2014) Ok, Mahmut; Yildiz, Ramazan; Naseri, AmirIn this case report, the ultrasonographic appearance of the abomasum, changes in some biochemical and blood gases parameters in a cow with anterior abomasal displacement (ADA) were described. Hyperbasemia, hypokalemia, hypocalcemia and hyperlactatemia in the cow with anterior abomasal displacement was detected. Displaced abomasum was imaged approximately 10 cm cranial of the xyphoid process from the left and and right paramedian regions and from the ventral abdomen midline, immediately caudal to the reticulum. This aim of case report was to contribute to the litature data for anterior abomasal displacement that can be also rare in cows.