Pharmacokinetics of pentoxifylline and its 5-hydroxyhexyl metabolite following intravenous administration in cattle
Yükleniyor...
Dosyalar
Tarih
2019
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
SPRINGER
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
This study investigated the pharmacokinetics of pentoxifylline (PTX) and its 5-hydroxyhexyl metabolite (M-I) after single-dose intravenous (IV) administration (10mg/kg) of PTX in six healthy cattle. The safety of PTX was evaluated by clinical observation and biochemical analysis. Plasma concentrations of PTX and M-I were simultaneously determined by reverse-phase high performance liquid chromatography. Pharmacokinetic parameters were calculated using non-compartmental methods. Salivation and discomfort were observed for 2h following the drug administration. Serum direct bilirubin, total bilirubin, and phosphorus levels at 24h following the drug administration were significantly different from the control values (0h) (P<0.05). Pharmacokinetic variables of PTX were characterized by a short terminal elimination half-life (1.05 +/- 0.19h), a large volume of distribution (6.30 +/- 1.76L/kg), and high total body clearance (5.31 +/- 1.27L/h/kg). The mean ratio between the area under the concentration-time curves of M-I and PTX was 1.34. These results indicate that single-dose administration of PTX at 10mg/kg IV in cattle resulted in therapeutic concentrations similar to those observed in humans and horse. However, further studies are necessary to determine the safety and pharmacokinetics following repeated administrations of PTX.
Açıklama
Anahtar Kelimeler
Pentoxifylline, M-I metabolite, Pharmacokinetics, Intravenous, Cattle
Kaynak
TROPICAL ANIMAL HEALTH AND PRODUCTION
WoS Q Değeri
Q2
Scopus Q Değeri
Q2
Cilt
51
Sayı
2
Künye
Uney, K., Tras, B., Corum, O., Yildiz, R., Maden, M. (2019). Pharmacokinetics Of Pentoxifylline And İts 5-Hydroxyhexyl Metabolite Following İntravenous Administration İn Cattle. Tropical Animal Health And Production, 51,(2), 435-441.
