Pharmacokinetics of pentoxifylline and its 5-hydroxyhexyl metabolite following intravenous administration in cattle

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dc.contributor.authorUney, Kamil
dc.contributor.authorTras, Bunyamin
dc.contributor.authorCorum, Orhan
dc.contributor.authorYildiz, Ramazan
dc.contributor.authorMaden, Mehmet
dc.date.accessioned2020-03-26T20:19:07Z
dc.date.available2020-03-26T20:19:07Z
dc.date.issued2019
dc.departmentSelçuk Üniversitesi, Veteriner Fakültesi, Klinik Öncesi Bilimler Bölümüen_US
dc.description.abstractThis study investigated the pharmacokinetics of pentoxifylline (PTX) and its 5-hydroxyhexyl metabolite (M-I) after single-dose intravenous (IV) administration (10mg/kg) of PTX in six healthy cattle. The safety of PTX was evaluated by clinical observation and biochemical analysis. Plasma concentrations of PTX and M-I were simultaneously determined by reverse-phase high performance liquid chromatography. Pharmacokinetic parameters were calculated using non-compartmental methods. Salivation and discomfort were observed for 2h following the drug administration. Serum direct bilirubin, total bilirubin, and phosphorus levels at 24h following the drug administration were significantly different from the control values (0h) (P<0.05). Pharmacokinetic variables of PTX were characterized by a short terminal elimination half-life (1.05 +/- 0.19h), a large volume of distribution (6.30 +/- 1.76L/kg), and high total body clearance (5.31 +/- 1.27L/h/kg). The mean ratio between the area under the concentration-time curves of M-I and PTX was 1.34. These results indicate that single-dose administration of PTX at 10mg/kg IV in cattle resulted in therapeutic concentrations similar to those observed in humans and horse. However, further studies are necessary to determine the safety and pharmacokinetics following repeated administrations of PTX.en_US
dc.identifier.citationUney, K., Tras, B., Corum, O., Yildiz, R., Maden, M. (2019). Pharmacokinetics Of Pentoxifylline And İts 5-Hydroxyhexyl Metabolite Following İntravenous Administration İn Cattle. Tropical Animal Health And Production, 51,(2), 435-441.
dc.identifier.doi10.1007/s11250-018-1710-8en_US
dc.identifier.endpage441en_US
dc.identifier.issn0049-4747en_US
dc.identifier.issn1573-7438en_US
dc.identifier.issue2en_US
dc.identifier.pmid30219998en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage435en_US
dc.identifier.urihttps://dx.doi.org/10.1007/s11250-018-1710-8
dc.identifier.urihttps://hdl.handle.net/20.500.12395/38087
dc.identifier.volume51en_US
dc.identifier.wosWOS:000457396300021en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorUney, Kamil
dc.institutionauthorTras, Bunyamin
dc.institutionauthorMaden, Mehmet
dc.language.isoenen_US
dc.publisherSPRINGERen_US
dc.relation.ispartofTROPICAL ANIMAL HEALTH AND PRODUCTIONen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectPentoxifyllineen_US
dc.subjectM-I metaboliteen_US
dc.subjectPharmacokineticsen_US
dc.subjectIntravenousen_US
dc.subjectCattleen_US
dc.titlePharmacokinetics of pentoxifylline and its 5-hydroxyhexyl metabolite following intravenous administration in cattleen_US
dc.typeArticleen_US

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