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Öğe A case of Sjogren's syndrome accompanied by signs of non-cardiac pulmonary edema and infection [Non-kardiyak akci?er ödemi ve enfeksiyon bulgularinin eşlik etti?i Sjögren sendromu olgusu](2013) Sümer S.; Efe P.B.; Ural O.; Yilmaz S.At first presentation connective tissue diseases may mimic infectious diseases. But recurrent non-cadiac pulmonary edema accompanied by serious infectious signs is observed rarely. This patient presented with signs of pneumonia, and developed recurrent non-cadiac pulmonary edema, and had to be intubated despite appropriate treatment and Sjögren's syndrome was diagnosed after examinations and detailed history which were warranted by lack of treatment response. She was treated with hydroxychloroquine. This patient's problem was thought to be due to both findings of systemic involvement of connective tissue disease and increased frequency of infectious diseases in these patients.Öğe Genetic alterations and nutritional habits among fast-food employees(Kluwer Academic Publishers, 2016) Ucar A.; Yilmaz S.; Karatas E.; Ozdogan Y.Fast food sector is growing due to changing lifestyles. This model is very popular in all over the world and it comes with the idea to evaluate certain health aspects in terms of employee health and safety which became more of an issue recently. Nutritional habits, physical activity levels and possible genetic changes related to nutrition among the fast-food employees were evaluated in this work. 24 hour food and physical activity level records were used to determine nutritional habits and physical activity levels of employees (n=26) and controls (n=19). Exfoliated buccal cells were used to determine genetic change level related to nutrition habit. It was found that the two groups’ energy intake was lower than the recommendation levels. But experimental groups’ activity level was too high. A significant increased incidence of changes between the controls and subjects were observed (P<0.05); a non-significant increase in females and a significant increase in males were also observed. Smoking habit did not significantly affect the genetic changes in both genders. Based on our results, the nutrition habit of the experimental group most probably affected their genome health. However further detailed work should be conducted to arrive at definite conclusion. © 2016, Korean Society of Environmental Risk Assessment and Health Science and Springer Science+Business Media Dordrecht.Öğe The role of prohepcidin and hepcidin in anemia associated with systemic lupus erythematosus(2011) Dagli M.; Yilmaz S.; Sivrikaya A.; Cehk G.; Vatansev H.The aim of the study is to investigate the role of circulating prohepcidin and hepcidin, a homeostatic regulator of iron metabolism and a mediator of inflammation, in anemia associated with systemic lupus erythematosus(SLE) and differential diagnosis of iron deficiency anemia (IDA). Fourty patients with SLE (12 with anemia and 28 without anemia), 30 patients with IDA and 20 healthy adults were studied. Serum prohepcidin and hepcidin levels were analyzed by using a commercially available kits (DRG prohepcidin and hepcidin ELISA kits). Serum prohepcidin and hepcidin levels in patients with SLE were significantly higher than those with IDA and healthy group. In the group with IDA and SLE positive correlation was determined between the values of serum prohepcidin, hepcidin, Hb, TIBC and ferritin. Serum prohepcidin and hepcidin levels are not closely associated with disease activity in patients with SLE, but might play a role in the pathobiology of chronic disease anemia associated with SLE. © IDOSI Publications, 2011.Öğe Serum prohepcidin and hepcidin levels in patients with rheumatoid arthritis: A prospective study [Romatoid artritli hastalarda serum hepsidin ve prohepsidin düzeyleri: Prospektif çali{dotless}şma](Turkiye Klinikleri, 2013) Da?li M.; Sivrikaya A.; Yilmaz S.Objective: Anemia of chronic disease is a common feature of active rheumatoid arthritis. Hepcidin is an acute-phase protein with specific iron regulatory properties, which along with the anemia seen with increased hepcidin expression, have led many to consider it the major mediator of anemia of chronic disease. The aim of this study was to evaluate the serum levels of hepcidin and its prohormone, prohepcidin, in patients with rheumatoid arthritis (RA) in comparison with healthy controls. Material and Methods: Fifty patients with RA and twenty healthy adults were prospectively enrolled. Complete blood count, erythrocyte sedimentation rate, serum hepcidin, prohepcidin, iron, total iron binding capacity, ferritin, transferrin and C-reactive protein levels were measured. Results: Serum prohepcidin and hepcidin levels were significantly higher in patients with RA compared to healthy controls (p=0.010). In patients with RA, a positive correlation was determined between the serum hepcidin and prohepcidin levels (r=0.725, p<0.001). Conclusion: Our findings suggest that hepcidin and prohepcidin are strongly associated with disease activity in RA patients and might play a significant role in the pathobiology of anemia of chronic disease associated with RA. Future studies to determine serum levels of hepcidin at different time points during the clinical course of RA patients will be needed to confirm our results. © 2013 by Türkiye Klinikleri.
