Yazar "Zorlu, Abdullah Faruk" seçeneğine göre listele

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    Accelerated Hyperfractionated Radiotherapy in Supratentorial Malignant Astrocytomas
    (Elsevier Sci Ireland Ltd, 2000) Genç, Mine; Zorlu, Abdullah Faruk; Atahan, İbtisam Lale
    Purpose: To determine the safety and effectiveness of accelerated hyperfractionated radiotherapy in the treatment of supratentorial malignant astrocytomas. Materials and methods: Between June 1995-July 1997, 75 patients were enrolled to a prospective phase II study. A total dose of 60 Gy was delivered in 2 Gy b.i.d. fractions with an interval of 6-8 h, 5 days per week, in an overall time of 3 weeks. The treatment protocol was planned to give 40 Gy to a treatment volume covering the contrast-enhancing lesion and oedema (+ 3-cm margin) and additional 20 Gy to the volume encompassing the contrast-enhancing lesion alone with a I-cm margin based on preoperative magnetic resonance imaging and/or CT findings. The patients had a median age of 46 years and a median Karnofsky performance status score of 80, Histology consisted of anaplastic astrocytoma (AA) in 16 (21%) and glioblastoma multiforme (GBM) in 59 (79%) patients. Results: Median survival was 11 months for all patients; 10 months for GEM patients and 40 months for AA patients. Survival rates at 1 and 3 years were 41%, 11% for all patients; 62, 37% for AA patients and 35, 6% for GEM patients, respectively. Multivariate analysis revealed significant impact of age, histology and neurological functional class on survival. The incidence of grade 3 or worse late neurological toxicity was 5.3%. Conclusions: Although accelerated hyperfractionated radiotherapy showed no significant advantage on survival, it shortened the treatment period from 6 to 3 weeks. Radiotherapy was well tolerated and the incidence of late toxicity is acceptable.
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    Results of Conventionally Fractionated Radiotherapy in Supratentorial Malignant Glioma Patients
    (2002) Gürkaynak, Murat; Genç, Mine; Zorlu, Abdullah Faruk; Akyol, Hüsnü Fadıl; Atahan, İbtisam Lale
    Sixty patients with the diagnosis of supratentorial malignant glial tumor, treated between November 1993-June 1997, were retrospectively analyzed. The patients had a median age of 47 years and a median Karnofsky Performance Status score of 90. Histology consisted of anaplastic astrocytoma in 21 (35%) and glioblastoma multiforme in 39 (65%) patients. Median survival was 13 months for all patients, 12 months for GBM patients and 43 months for AA patients. Survival rates at 1 and 3 years were 55%, 28% for all patients; 39%, 12% for GBM patients and 80%, 54% for AA patients, respectively. Univariate analysis revealed significant impact of histology, KPS, duration of symptoms and age on survival. KPS was found to be an independent prognostic factor according to multivariate analysis. These results were compared with literature.
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    Spinal seeding of pilocytic astrocytoma: Case report and review of the literature
    (2005) Gürkaynak, Murat; Büyükpamukçu, Münevver; Zorlu, Abdullah Faruk; Akalan, Nejat; Söylemezoğlu, Figen; Genç, Mine
    A case of cerebellar pilocytic astrocytoma who developed cranial and spinal seedings, 6 years after diagnosis, was presented. The patient was still alive with progressive intracranial and stabile spinal lesions 5 years after completion of radiotherapy.