Endoskopi Yapılan Olgularda Helicobacter Pylori Prevalansı, Tanı Metodları ve Hastalıklarla Olan İlişkisi
Küçük Resim Yok
Tarih
2002
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
AMAÇ: Özefagogastroduodenoskopi yapılan hastalarda Helikobakter pilori (Hp) sıklığını, hastalıklarla olan ilişkisini ve Hp tanısında kullanılan testlerin duyarlılığını araştırmak. GEREÇ VE YÖNTEM: Selçuk Üniversitesi Tıp Fakültesi İç Hastalıkları ve Genel Cerrahi Endoskopi Ünitesine endoskopi yapılması için gönderilen 302 olguda Hp varlığı ve endoskopik tanılarla olan ilişkisi araştırıldı. Tüm olgularda antrumdan üç adet biyopsi ve 5 cc venöz kan alındı. Biyopsi örnekleri Giemsa ve Hematoksilen-Eosin ile boyanarak incelendi. Bir örnek üreaz testinde kullanıldı. Kan örneğinden ELİSA yöntemi ile spesifik IgG ve IgA tayini yapıldı. İstatistiki incelemeler SPSS 10.0 programı yardımıyla Ki-kare ve Mc Nemar testleri ile değerlendirildi. BULGULAR: Olguların yaş ortalaması 47.316.1 olup, kadınlar %58 erkekler %42 oranındaydı. Endoskopik tanıda ilk sırada %38.4 ile gastrit saptandı. Mide kanseri %5'di. Tüm olgularda Hp serolojik yöntemle %74.5, üreaz ve/veya histolojik metotla %67.5 müspet bulundu. Yaş grupları ve cinsler arasında anlamlı farklılık bulunmadı. Duodenal ülserli hastalarda Hp pozitifliği tüm yöntemlerde anlamlı olarak yüksek (p0.05) bulundu. Meslek guruplarında Hp varlığı yönünden anlamlılık yoktu. En yüksek sensitivite serolojik yöntemde(%83.2), en yüksek spesifite üreaz testinde saptandı. SONUÇ: Endoskopik tanılar ile patolojik tanılar arasında gözlenen uyum %76.8 olarak tespit edildi.
AIM: The aim of the present study was to investigate the incidence of helicobacter pylori(Hp), its relation with diseases and the sensitivity of tests used in the diagnosis of Hp in patients underwent osefagogastroduodenoscopy. MATERIAL AND METHODS: The presence of Hp and its relation with endoscopic diagnosis was investigated in 302 patients applied to the clinics of internal diseases and general surgery of medical school of University of Selcuk, for endoscopy. 3 biopsy samples from antrum and 5 ml. Of blood samples were obtained from the patients. Biopsy samples were evaluated by Giemsa and Hematoxylene-eosine stain. One sample was used for urease test. Spesific IgG and IgA levels of blood samples were measured by ELISA method. Statistics were performed by Xi-square and Mc Nemar tests using the SPSS 10.0 programme. RESULTS: The patients(58% Female, 42% Male) were 47.3±16.1 years old. Gastritis was diagnosed in 38.4% of them by endoscopic evaluation, whereas gastric cancer was 5%. Hp was diagnosed in 74.5% of the cases by serologic methods and 67.5% by urease and/or histologic method. There was no significant difference between age groups and sexes. The possibility of Hp in patients with duodenal ulcer was significantly(p< 0.05) positive by all methods. No significant difference was found between profession groups. The highest sensitivity was found in serological tests(83.2%) and the highest sensitivity in urease test. CONCLUSION: 76.8% correlation was found between endoscopic and pathologic diagnosis.
AIM: The aim of the present study was to investigate the incidence of helicobacter pylori(Hp), its relation with diseases and the sensitivity of tests used in the diagnosis of Hp in patients underwent osefagogastroduodenoscopy. MATERIAL AND METHODS: The presence of Hp and its relation with endoscopic diagnosis was investigated in 302 patients applied to the clinics of internal diseases and general surgery of medical school of University of Selcuk, for endoscopy. 3 biopsy samples from antrum and 5 ml. Of blood samples were obtained from the patients. Biopsy samples were evaluated by Giemsa and Hematoxylene-eosine stain. One sample was used for urease test. Spesific IgG and IgA levels of blood samples were measured by ELISA method. Statistics were performed by Xi-square and Mc Nemar tests using the SPSS 10.0 programme. RESULTS: The patients(58% Female, 42% Male) were 47.3±16.1 years old. Gastritis was diagnosed in 38.4% of them by endoscopic evaluation, whereas gastric cancer was 5%. Hp was diagnosed in 74.5% of the cases by serologic methods and 67.5% by urease and/or histologic method. There was no significant difference between age groups and sexes. The possibility of Hp in patients with duodenal ulcer was significantly(p< 0.05) positive by all methods. No significant difference was found between profession groups. The highest sensitivity was found in serological tests(83.2%) and the highest sensitivity in urease test. CONCLUSION: 76.8% correlation was found between endoscopic and pathologic diagnosis.
Açıklama
Anahtar Kelimeler
Genel ve Dahili Tıp
Kaynak
Medical Network Klinik Bilimler ve Doktor
WoS Q Değeri
Scopus Q Değeri
Cilt
8
Sayı
1
Künye
Karataş, A., Polat, H., Aksoy, F., Vatansev, C., (2002). Endoskopi Yapılan Olgularda Helicobacter Pylori Prevalansı, Tanı Metodları ve Hastalıklarla Olan İlişkisi. Medical Network Klinik Bilimler ve Doktor, 8(1), 5-12.
