Enzyme inhibitory effect and antioxidant properties of astragalus lagurus extracts

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dc.contributor.authorZengin, Gökhan
dc.contributor.authorCeylan, Ramazan
dc.contributor.authorGüler, Gökalp Özmen
dc.contributor.authorCarradori, S.
dc.contributor.authorUysal, Şengül
dc.contributor.authorAktümsek, Abdurrahman
dc.date.accessioned2020-03-26T19:31:59Z
dc.date.available2020-03-26T19:31:59Z
dc.date.issued2016
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractAntioxidant and enzyme inhibitory effects (against cholinesterase, tyrosinase, ?-amylase and ?-glucosidase) of ethyl acetate, methanol, and aqueous extracts from Astragalus lagurus (Fabaceae) were investigated with spectrophotometric methods. Antioxidant capacity were evaluated by using different assay including free radical scavenging (DPPH and ABTS), reducing power (FRAP and CUPRAC), phosphomolybdenum, and metal chelating experiments. Total phenolic and flavonoid content was also determined as 20.34-20.72 mg GAEs/g and 19.58-31.10 mg REs/g, respectively. Generally, A. lagurus ethyl acetate and aqueous extracts were observed to possess higher antioxidant and enzyme inhibitory effects compared to methanol extract. The aqueous extract exhibited the strongest free radical scavenging activity on DPPH (20.65 mg TEs/g) and ABTS (67.43 mg TEs/g) as well as on reducing power tests (73.98 mg TEs/g for CUPRAC and 53.49 mg TEs/g for FRAP). ş-Amylase and ?-glucosidase inhibition were found to be 0.12-0.56 and 1.45-1.82 mmol ACAEs/g. These findings suggest that A. lagurus could provide natural biologically active agents to be used in food and pharmaceutical industry. © 2016 Bentham Science Publishers.en_US
dc.identifier.doi10.2174/1573408012666160127231058en_US
dc.identifier.endpage182en_US
dc.identifier.issn1573-4080en_US
dc.identifier.issue2en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage177en_US
dc.identifier.urihttps://dx.doi.org/10.2174/1573408012666160127231058
dc.identifier.urihttps://hdl.handle.net/20.500.12395/34275
dc.identifier.volume12en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherBentham Science Publishers B.V.en_US
dc.relation.ispartofCurrent Enzyme Inhibitionen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectAntioxidanten_US
dc.subjectAstragalusen_US
dc.subjectEnzyme inhibitionen_US
dc.subjectPhenolicen_US
dc.subjectTurkeyen_US
dc.titleEnzyme inhibitory effect and antioxidant properties of astragalus lagurus extractsen_US
dc.typeArticleen_US

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