Investigation of the metal bonding properties of some ARA-II compounds using spectrofluorimetric method

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dc.contributor.authorBeniz Gündüz S.
dc.contributor.authorDönertaş A.
dc.date.accessioned2020-03-26T19:08:24Z
dc.date.available2020-03-26T19:08:24Z
dc.date.issued2015
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractThe metal bonding properties of some ARA-II (Angiotensin II Receptor Antagonists) compounds, such as valsartan (VAL), were investigated by using spectrofluorimetric method. Fluorescence quenching of VAL by Cu(II) was studied and optimal experimental conditions were determined. The excitation and emission wavelengths were ?ex= 280 nm and ?em= 436 nm for the Cu(II)-VAL complex in methanol medium. The calibration curve was obtained from Stern-Volmer equation plotting to F0/F-[Cu+2. graphs and the linearity was found within the range of 0.25-2.54 ?g.ml-1 for the Cu(II)-VAL complex under optimal conditions. The detection limit (LOD) and the quantitation limits (LOQ) of the proposed method for this complex were 4.96 ng.ml-1 and 16.53 ng.ml-1 respectively. The stochiometry of this complex was also determined by using the continuous variation method and the molar ratio of Cu(II):VAL was calculated as 1:1. The interaction between the valsartan in tablet form and Cu(II) in the vitamin-mineral combination tablet was investigated by applying this quenching method and obtained satisfactory results. © 2014 Bentham Science Publishers.en_US
dc.identifier.endpage293en_US
dc.identifier.issn1574-8855en_US
dc.identifier.issue4en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage285en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12395/32835
dc.identifier.volume9en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherBentham Science Publishers B.V.en_US
dc.relation.ispartofCurrent Drug Therapyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectCu(II) complexen_US
dc.subjectFluorescence quenchingen_US
dc.subjectPharmaceutical analysisen_US
dc.subjectValsartanen_US
dc.titleInvestigation of the metal bonding properties of some ARA-II compounds using spectrofluorimetric methoden_US
dc.typeArticleen_US

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