Fertil ve infertil şahıslarda seminal sıvı, serum lipid ve testosteron düzeyinin araştırılması
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Tarih
2005
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Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Amaç: Fertil ve infertil şahıslarda seminal sıvı ile serum lipid ve testosteron seviyeleri arasındaki ilişkinin araştırılması. Çalışmanın yapıldığı yer: Selçuk Üniversitesi, Meram Tıp Fak., Biyokimya ABD, KONYA Materyal ve Metod: Çalışmamızda 21-32yaşları arasında (ortalama 25) 25 fertil şahıs ile 18-42 yaşları arasında (ortalama 29) 30 intertil şahısta serum trigliserid (TG), total kolesterol, yüksek dansiteli lipoprotein (HDL) kolesterol, düşük dansiteli lipoprotein (LDL) kolesterol, total ve serbest testosteron ile seminal sıvı analizi yapıldı. Bütün analizler rutin metodlarla gerçekleştirildi. Bulgular: Fertil şahıslarda total ve serbest testosteron düzeyleri infertil şahıslarınkinden hafif yüksek iken, total kolesterol düzeyleri anlamlı decede düşük, sperm sayısı ise anlamlı derecede yüksekti. İnfertil grupta serum total kolesterol düzeyi ile serum total ve serbest testosteron düzeyleri arasında önemli negatif korelasyon, tüm vakalarda ise serum total kolesterol düzeyi ile sperm sayısı arasında önemli negatif korelasyon bulundu. Sonuç: Bu bulgular, hiperkolesteroleminin koroner kalp hastalığı riski yanında azospermiye ve sonuçta infertiliteye de yol açabileceğini göstermektedir. Bulgularımız, çeşitli araştırmacıların bulguları ile uyum halinde olup literatür bulguları ışığında tartışıldı.
Objective: To investigate the correlation between semi¬nal fluid parameters, serum lipids and testosterone levels in fertile and infertile subjects. Institution: Selçuk University, Meram Faculty of Medicine, Department of Biochemistry, KQNYA Material and Methods: In this study, we have investigated serum triglyceride (TG), total cholesterol, high density lipoprotein (HDL) cholesterol, low density lipoprotein (LDL) cholesterol, total and free testosteron levels and seminal fluid parameters of 25 fertile subjects aged 21-32 years (mean 25) and 30 infertile subjects aged 18-42 years (mean 29). All analysis were performed by routine methods. Results: Total and free testosteron levels of fertile subjects were slightly higher while total cholesterol levels were significantly lower and sperm count significantly higher than those of the infertile subjects. There was a significant negative correlation between serum total cholesterol and serum total and free testosteron levels in infertile subjects. Also, there was a significant correlation between total cholesterol levels and sperm count of all subjects. Conclusion: These findings suggests that hypercholes-terolemia may cause azoospermia and, hence results in infertility in addition to the risk of coronary artery disease. Our findings were in accordance with those of other investigators and discussed in view of literature.
Objective: To investigate the correlation between semi¬nal fluid parameters, serum lipids and testosterone levels in fertile and infertile subjects. Institution: Selçuk University, Meram Faculty of Medicine, Department of Biochemistry, KQNYA Material and Methods: In this study, we have investigated serum triglyceride (TG), total cholesterol, high density lipoprotein (HDL) cholesterol, low density lipoprotein (LDL) cholesterol, total and free testosteron levels and seminal fluid parameters of 25 fertile subjects aged 21-32 years (mean 25) and 30 infertile subjects aged 18-42 years (mean 29). All analysis were performed by routine methods. Results: Total and free testosteron levels of fertile subjects were slightly higher while total cholesterol levels were significantly lower and sperm count significantly higher than those of the infertile subjects. There was a significant negative correlation between serum total cholesterol and serum total and free testosteron levels in infertile subjects. Also, there was a significant correlation between total cholesterol levels and sperm count of all subjects. Conclusion: These findings suggests that hypercholes-terolemia may cause azoospermia and, hence results in infertility in addition to the risk of coronary artery disease. Our findings were in accordance with those of other investigators and discussed in view of literature.
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Kaynak
Türk Fertilite Dergisi
WoS Q Değeri
Scopus Q Değeri
Cilt
13
Sayı
1
