Systemic effects of epidural betamethasone injection

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dc.contributor.authorTuncer S.
dc.contributor.authorBarişkaner H.
dc.contributor.authorYosunkaya A.
dc.contributor.authorReisli R.
dc.contributor.authorÖkesli S.
dc.date.accessioned2020-03-26T16:55:51Z
dc.date.available2020-03-26T16:55:51Z
dc.date.issued2004
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractA single epidural injection of a steroid may produce a suppression of the adrenocortical secretion. We aimed to evaluate systemic effects of a single epidural injection of betamethasone in this study. The study included 33 patients with low back pain. None of the patients had received local or systemic steroid therapy within 2 months before the injection. The epidural injection consisted of 10 mg of betamethasone diluted in 8 ml 0.25% bupivacaine. Injections were performed between 8:00 and 9:00 a.m. Before the injection in the same day (D0) cortisol, ACTH, fasting levels of glucose, triglycerides, cholesterol, sodium, and potassium were checked in the blood. The same assays were done again by the same laboratory at 15, 30, 45 min, and 7 (D7) and 21 (D21) days after the steroid injections. In all patients, cortisol and ACTH were normal at D0. ACTH and cortisol significantly decreased 45 min and at D7 after steroid injection, but returned to normal on D21. There were no significant changes in mean fasting glucose, sodium, potassium, triglycerides or cholesterol levels during the study. Blood pressure values were normal in all patients. As a result, it is concluded that a single epidural injection of betamethasone is associated with transient adrenal suppression.en_US
dc.identifier.doi10.1163/1568569041798461en_US
dc.identifier.endpage315en_US
dc.identifier.issn0169-1112en_US
dc.identifier.issue3en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage311en_US
dc.identifier.urihttps://dx.doi.org/10.1163/1568569041798461
dc.identifier.urihttps://hdl.handle.net/20.500.12395/19371
dc.identifier.volume16en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.relation.ispartofPain Clinicen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectBetamethasoneen_US
dc.subjectEpidural injectionen_US
dc.subjectSystemic effectsen_US
dc.titleSystemic effects of epidural betamethasone injectionen_US
dc.typeArticleen_US

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