A CASE OF PAGET'S DISEASE OF THE BONEPRESENTED WITH HEARING LOSS AS THEFIRST SYMPTOM
Küçük Resim Yok
Tarih
2014
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Altmış yedi yaşında kadın hasta, her iki kulakta işitme kaybı nedeniyle odyoloji polikliniğinebaşvurdu. İki yıldır şikayeti olan hastanın rutin serum biyokimya incelemesinde alkalen fosfataz değerinin 381 U/L olması üzerine endokrinoloji ünitemize yönlendirildi. Hastanın vitamin D,parathormon, tiroid fonksiyon testleri, karaciğer fonksiyon testleri, böbrek fonksiyon testleri normal sınırlar içindeydi. Hastanın kranial grafisinde; diploe mesafesinde artış, kalvaryumda sklerotikgörünüm ve tüm vücut kemik sintigrafisinde; kalvaryumda diffüz tarzda artmış radyoaktif maddetutulumu izlendi. Serum osteokalsin ve spot idrarda deoksipridinolin düzeyleri yüksek saptandı.İşitme kaybının ilk semptom olarak görüldüğü hastaya mevcut bulgular ile kemiğin paget hastalığıtanısı ile zolendronik asit tedavisi verildi. Tedaviden üç ay sonraki kontrolünde, alkalen fosfatazdeğerinde normal düzeye gerileme ve odyolojik incelemede hafif düzeyde bir düzelme izlendi
A67-year-old woman presented to the audiology clinic with a complaint of bilateral hearing lossover the past two years. Routine biochemical screening showed an alkaline phosphatase levelof 381 U/L, and she was referred to our endocrinology unit. Her vitamin D and parathyroid hormone levels, as well as thyroid, liver and kidney function test results, were within normal ranges.Cranial x-ray radiography showed an increase in the diploe distance and a sclerotic pattern in thecalvarium; while whole body bone scintigraphy demonstrated a diffuse increase in radioactivesubstance involvement of the calvarium. Serum osteocalcin and spot urinary deoxypyridinolinelevels were increased. The patient was diagnosed with Paget's disease with hearing loss as thefirst symptom, and she was started taking zoledronic acid treatment. Three months later, heralkaline phosphatase level had returned to the normal range, and audiologic examinationshowed a mild improvement in hearing
A67-year-old woman presented to the audiology clinic with a complaint of bilateral hearing lossover the past two years. Routine biochemical screening showed an alkaline phosphatase levelof 381 U/L, and she was referred to our endocrinology unit. Her vitamin D and parathyroid hormone levels, as well as thyroid, liver and kidney function test results, were within normal ranges.Cranial x-ray radiography showed an increase in the diploe distance and a sclerotic pattern in thecalvarium; while whole body bone scintigraphy demonstrated a diffuse increase in radioactivesubstance involvement of the calvarium. Serum osteocalcin and spot urinary deoxypyridinolinelevels were increased. The patient was diagnosed with Paget's disease with hearing loss as thefirst symptom, and she was started taking zoledronic acid treatment. Three months later, heralkaline phosphatase level had returned to the normal range, and audiologic examinationshowed a mild improvement in hearing
Açıklama
Anahtar Kelimeler
Cerrahi
Kaynak
Türk Geriatri Dergisi
WoS Q Değeri
Scopus Q Değeri
Cilt
17
Sayı
2
