The association between myocardial iron load and ventricular repolarization parameters in asymptomatic beta-thalassemia patients

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dc.contributor.authorKayrak, Mehmet
dc.contributor.authorAcar, Kadir
dc.contributor.authorGül, Enes Elvin
dc.contributor.authorÖzbek, Orhan
dc.contributor.authorAbdulhalikov, Turyan
dc.contributor.authorSönmez, Osman
dc.contributor.authorAlibaşiç, Hayruddin
dc.date.accessioned2020-03-26T18:33:00Z
dc.date.available2020-03-26T18:33:00Z
dc.date.issued2012
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractPrevious studies have demonstrated impaired ventricular repolarization in patients with ?-TM. However, the effect of iron overload with cardiac T 2 * magnetic resonance imaging (MRI) on cardiac repolarization remains unclear yet. We aimed to examine relationship between repolarization parameters and iron loading using cardiac T 2 * MRI in asymptomatic ?-TM patients. Twenty-two ?-TM patients and 22 age- and gender-matched healthy controls were enrolled to the study. From the 12-lead surface electrocardiography, regional and transmyocardial repolarization parameters were evaluated manually by two experienced cardiologists. All patients were also undergone MRI for cardiac T 2 * evaluation. Cardiac T 2 * score <20msec was considered as iron overload status. Of the QT parameters, QT duration, corrected QT interval, and QT peak duration were significantly longer in the ?-TM group compared to the healthy controls. T p - T e and T p - T e dispersions were also significantly prolonged in ?-TM group compared to healthy controls. (T p - T e) / QT was similar between groups. There was no correlation between repolarization parameters and cardiac T 2 * MRI values. In conclusion, although repolarization parameters were prolonged in asymptomatic ?-TM patients compared with control, we could not find any relation between ECG findings and cardiac iron load. Copyright © 2012 Mehmet Kayrak et al.en_US
dc.identifier.doi10.1155/2012/170510en_US
dc.identifier.issn1687-9104en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.urihttps://dx.doi.org/10.1155/2012/170510
dc.identifier.urihttps://hdl.handle.net/20.500.12395/28819
dc.identifier.volume2012en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.relation.ispartofAdvances in Hematologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.titleThe association between myocardial iron load and ventricular repolarization parameters in asymptomatic beta-thalassemia patientsen_US
dc.typeArticleen_US

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