Gestasyonel diabetes mellitus tanısında bir biyobelirteç olarak serumprokalsitonin düzeyi
Küçük Resim Yok
Tarih
2018
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Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Amaç: Bu çalışmanın amacı gestasyonel diabetes mellitus hastalarında ve sağlıklı gebelerde serum prokalsitonin düzeylerini karşılaştırmak ve prokalsitonin düzeyinin diğer metabolik parametreler ile ilişkisini değerlendirilmesidir.Gereç ve Yöntem: Endokrinoloji Bilim Dalı polikliniğine başvuran 142 gebe çalışmaya dahil edildi. Oral glukoz tolerans testi sonuçlarına göre 57 gebeye gestasyonel diabet mellitus tanısı konuldu. 85 sağlıklı gebe ise kontrol grubuna dahil edildi. Serum analizi için tüm kan örnekleri bir gecelik açlık sonrası oral glukoz tolerans testi başlangıcında sabah 7:00 ve 8:00 saatleri arasında alındı. Bulgular: Gestasyonel diabet mellitus grubunda serum prokalsitonin düzeyleri kontrol grubuna göre anlamlı olarak yüksek bulundu. Serum prokalsitonin düzeyi ile açlık glukozu ve oral glukoz tolerans testi 60. dakika glukoz düzeyleri arasında anlamlı pozitif korelasyon bulundu. Sonuç: Bu çalışmada gestasyonel diabet mellitus'lu gebelerde serum prokalsitonin düzeylerinin sağlıklı gebelere göre anlamlı olarak yüksek olduğu ilk kez gösterilmiştir. Bu sonuç kronik düşük-dereceli inflamasyonun gestasyonel diabet mellitus patogenezinde önemli role sahip olduğu bilgisini desteklemektedir. Prokalsitonin düzeyi gestasyonel diabet mellitus hastalarında kronik düşük-dereceli inflamasyonun yeni bir biyobelirteci olarak düşünülebilir.
Purpose: The aim of this study was set as to compare procalcitonin levels of gestational diabetes mellitus patients and healthy pregnant individuals and evaluate link between serum procalcitonin concentration and metabolic parameters of gestational diabetes mellitus. Materials and Methods: 142 pregnant individual who consulted to Endocrinology Division were taken to the study. According to the oral glucose tolerance test results, 57 were diagnosed gestational diabetes mellitus, and 85 healthy pregnant were included in the control group. For the serum analysis, samples were obtained after overnight fasting and between 7:00 AM and 8:00 AM. Results: In the gestational diabetes mellitus group serum procalcitonin levels was found significantly higher than control group. A positive correlation was found between serum procalcitonin levels and fasting glucose and oral glucose tolerance test 60. minute glucose levels. Conclusion: Our results shown that levels of serum procalcitonin in gestational diabetic mellitus were significantly higher than healthy pregnancies for the first time. This result supports the knowledge that chronic lowgrade inflammation plays an important role in the pathogenesis of gestational diabetes mellitus. Procalcitonin level may be considered as a new biomarker for chronic low-grade inflammation in patients with gestational diabetes mellitus.
Purpose: The aim of this study was set as to compare procalcitonin levels of gestational diabetes mellitus patients and healthy pregnant individuals and evaluate link between serum procalcitonin concentration and metabolic parameters of gestational diabetes mellitus. Materials and Methods: 142 pregnant individual who consulted to Endocrinology Division were taken to the study. According to the oral glucose tolerance test results, 57 were diagnosed gestational diabetes mellitus, and 85 healthy pregnant were included in the control group. For the serum analysis, samples were obtained after overnight fasting and between 7:00 AM and 8:00 AM. Results: In the gestational diabetes mellitus group serum procalcitonin levels was found significantly higher than control group. A positive correlation was found between serum procalcitonin levels and fasting glucose and oral glucose tolerance test 60. minute glucose levels. Conclusion: Our results shown that levels of serum procalcitonin in gestational diabetic mellitus were significantly higher than healthy pregnancies for the first time. This result supports the knowledge that chronic lowgrade inflammation plays an important role in the pathogenesis of gestational diabetes mellitus. Procalcitonin level may be considered as a new biomarker for chronic low-grade inflammation in patients with gestational diabetes mellitus.
Açıklama
Anahtar Kelimeler
Cerrahi
Kaynak
Çukurova Üniversitesi Tıp Fakültesi Dergisi
WoS Q Değeri
Scopus Q Değeri
Cilt
43
Sayı
1
