Electrocardiographic evaluation the effect of thiamine hydrochloride on Ttriton X-100 induced hyperlipidemia in rats
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Dosyalar
Tarih
2024
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Selçuk Üniversitesi
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Amaç: Hiperlipidemi, dünya genelinde yaygın bir durum olup kardiyovasküler hastalıklara önemli katkıda bulunur. Bu çalışma, Triton X-100 ile indüklenen hiperlipidemili ratlarda tiamin hidroklorürün lipid profilleri ve EKG değişiklikleri üzerindeki etkilerini araştırmaktadır.
Gereç ve Yöntem: On sekiz erkek Wistar Albino sıçanı üç gruba ayrıldı: Kontrol, Triton X-100 ve Triton X-100 + Tiamin. Hiperlipidemi, Triton X-100 (100 mg/kg, tek doz, intraperitoneal) kullanılarak indüklendi. Hiperlipidemi indüksiyonundan yetmiş iki saat sonra, tiamin hidroklorür, 7 gün boyunca günde 25 mg/kg dozunda intraperitoneal olarak uygulandı. EKG verileri kaydedildi ve serum biyokimyasal parametreleri analiz edildi.
Bulgular: Tiamin tedavisi, Triton X-100 ile indüklenen yüksek total kolesterol ve trigliserid seviyelerini önemli ölçüde azalttı. Ayrıca koroner risk indeksini iyileştirdi ve kalp hızı ile RR aralığı gibi EKG parametrelerini normale döndürdü. ST segment yükselmesi ve atriyal fibrilasyon gibi EKG anormallikleri, tiamin tedavisi uygulanan grupta daha az sıklıkla gözlendi.
Öneri: Tiamin hidroklorür, hiperlipidemiyi ve buna bağlı kardiyovasküler riskleri etkili bir şekilde hafifletmekte olup, terapötik bir ajan olarak potansiyelini göstermektedir. Dislipidemi ve kardiyovasküler hastalıkların yönetiminde klinik uygulamaları derinlemesine anlamak için ek bilgi ve araştırma gereklidir.
Aim: Hyperlipidemia, a prevalent condition globally, contributes significantly to cardiovascular diseases. This research focuses on the impacts of thiamine hydrochloride on lipid profiles and ECG changes in rats with Triton X-100-induced hyperlipidemia. Materials and Methods: A total of eighteen male Wistar Albino rats were divided into three groups: control, Triton X-100, and Triton X-100 +Thiamine. To induce hyperlipidemia, Triton X-100 was administered as a single intraperitoneal dose of 100 mg/kg. Thiamine hydrochloride was then given intraperitoneally at a dose of 25 mg/kg daily for 7 days, starting 72 hours after the induction of hyperlipidemia. ECG data were recorded, and serum biochemical parameters were analyzed. Results: Thiamine treatment significantly reduced elevated total cholesterol and triglyceride levels induced by Triton X-100. It also improved the coronary risk index and normalized ECG characteristics include the heart rate and the RR interval. ECG abnormalities, including ST segment elevation and atrial fibrillation, were less frequent in the thiamine-treated group. Conclusion:Thiaminehydrochloride effectivelymitigateshyperlipidemia and its associated cardiovascular risks, suggesting its potential as a therapeutic agent. Further research is needed to explore its clinical applications in managing dyslipidemia and cardiovascular diseases.
Aim: Hyperlipidemia, a prevalent condition globally, contributes significantly to cardiovascular diseases. This research focuses on the impacts of thiamine hydrochloride on lipid profiles and ECG changes in rats with Triton X-100-induced hyperlipidemia. Materials and Methods: A total of eighteen male Wistar Albino rats were divided into three groups: control, Triton X-100, and Triton X-100 +Thiamine. To induce hyperlipidemia, Triton X-100 was administered as a single intraperitoneal dose of 100 mg/kg. Thiamine hydrochloride was then given intraperitoneally at a dose of 25 mg/kg daily for 7 days, starting 72 hours after the induction of hyperlipidemia. ECG data were recorded, and serum biochemical parameters were analyzed. Results: Thiamine treatment significantly reduced elevated total cholesterol and triglyceride levels induced by Triton X-100. It also improved the coronary risk index and normalized ECG characteristics include the heart rate and the RR interval. ECG abnormalities, including ST segment elevation and atrial fibrillation, were less frequent in the thiamine-treated group. Conclusion:Thiaminehydrochloride effectivelymitigateshyperlipidemia and its associated cardiovascular risks, suggesting its potential as a therapeutic agent. Further research is needed to explore its clinical applications in managing dyslipidemia and cardiovascular diseases.
Açıklama
Anahtar Kelimeler
Elektrokardiyografi, Hiperlipidemi, Lipid Profilleri, Tiamin Hidroklorür, Triton X-100, Electrocardiography, Hyperlipidemia, Lipid Profiles, Thiamine Hydrochloride
Kaynak
Eurasian Journal of Veterinary Sciences
WoS Q Değeri
Scopus Q Değeri
Cilt
40
Sayı
3
Künye
Ozdemir MT and Ekici M, 2024. Electrocardiographic evaluation the effect of thiamine hydrochloride on Triton X-100 induced hyperlipidemia in rats. Eurasian J Vet Sci, 40, 3, 115-122. 10.15312/EurasianJVetSci.2024.435
