The effects of trans-9 18:1 octadecenoic acid isomer on levels of sICAM-1, sVICAM-1 and IGF-1
Küçük Resim Yok
Tarih
2011
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
WALTER DE GRUYTER GMBH
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Objective: The effects of trans-9 18: 1 octadecenoic acid isomer from the fatty acid isomers taken with diet on soluble cell adhesion molecules (sICAM-1: Soluble intercellular adhesion molecule-1 and sVCAM-1: Soluble vascular cell adhesion molecule-1) and insulin like growth factor-1 (IGF-1) levels were investigated on rats. Method: The rats which were fed for two weeks by the same diet were separated into experimental and control groups. Fifty mg/day trans-9 18: 1 octadecenoic acid isomer was added to the diet of experimental group for 10 days. Following the completion of special diet, fatty acid composition in both groups was studied by gas chromatography analysis. Results: Trans-9 18: 1 fatty acid level in the experimental group was higher than control group (p<0.01). The soluble cell adhesion molecules (sICAM-1 and sVCAM-1) increased (p<0.01) and IGF-1 levels decreased (p<0.05) in rats fed with trans-9 18: 1 octadecenoic acid. Conclusion: Our results indicate that, high levels of dietary trans fatty acid isomers are a factor in the increasing of cell adhesion molecules (sICAM-1, sVCAM-1) levels and decreasing of IGF-1 levels. Hence, measurement of these parameters may be beneficial in patients with coronary artery disease and atherosclerosis, as well as in other pathological cases. We believe that these parameters may also be useful for early diagnosis.
Açıklama
Anahtar Kelimeler
Trans fatty acid, Trans-9 18:1 octadecanoic acid, elaidic acid (C18:1 omega-9), oleic acid, sICAM-1, sVCAM-1, IGF-1
Kaynak
TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI
WoS Q Değeri
Q4
Scopus Q Değeri
Cilt
36
Sayı
1
