Phytochemical and Pharmacological Profile of Origanum Sipyleum Extracts: Exploring Novel Sources for Potential Pharmaceutical, Food, and Cosmetic Applications

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dc.contributor.authorFerrante, Claudio
dc.contributor.authorZengin, Gökhan
dc.contributor.authorOrlando, Giulia
dc.contributor.authorRecinella, Lucia
dc.contributor.authorChiavaroli, Annalisa
dc.contributor.authorLeone, Silvia
dc.contributor.authorBrunetti, L.
dc.contributor.authorMenghini, Luigi
dc.date.accessioned2020-03-26T20:19:09Z
dc.date.available2020-03-26T20:19:09Z
dc.date.issued2019
dc.departmentSelçuk Üniversitesi, Fen Fakültesi, Biyoloji Bölümüen_US
dc.description67th International Congress and Annual Meeting of the Society-for-Medicinal-Plant-and-Natural-Product-Research (GA) -- SEP 01-05, 2019 -- Innsbruck, AUSTRIAen_US
dc.description.abstractOriganum sipyleum L., an endemic plant of Western Anatolia has been used as a medicinal tea, food additive, and for the production of essential oil. In this study, the biological potential of three extracts (ethyl acetate, methanol, and aqueous) of O. sipyleum was assessed based on antioxidant activity against key enzymes of clinical relvance. The chemical profile of the plant was assessed using spectrophotometric and LC-MS techniques. Additionally, we explored potential antioxidant and anti-inflammatory effects duced by the extracts in an experimental model of ulcerative colitis induced by LPS challenging. LC-MS analysis revealed that the extracts contained different classes of phenolics, such as rosmarinic acid, phlorizin and gallic acid. We found that the aqueous extract was the most effective antioxidant, displaying the highest DPPH and ABTS scavenging, FRAP, CUPRAC, molybdenum(VI) reducing, and metal chelating effect. The aqueous extract howed the strongest acetylcholinesterase (AChE) inhibition; the methanol extract showed the highest ?-glucosidase inhibition, while the ethyl acetate extract was the most effective on butyrylcholinesterase (BChE), tyrosinase, and ?-amylase. The total flavonoid content was highest in the aqueous and ethyl acetate extract, respectively. Finally, we found that all extracts were effective in reducing LPS-induced activity of pro-oxidant and pro-inflammatory biomarkers including nitrites, LDH, PGE2 and 5-HT, in rat colon, with the best activity showed by ethyl acetate extract. Our results indicated that the three solvent extracts varied in their chemical and biological profiles, but overall, O. sipyleum showed promising therapeutic properties, nonetheless, need to be further validated in in vivo models.en_US
dc.description.sponsorshipSoc Med Plant & Nat Prod Res, French Soc Pharmacognosyen_US
dc.identifier.citationFerrante, C., Zengin, G., Orlando, G., Recinella, L., Chiavaroli, A., Leone, S., Brunetti, L., Menghini, L. (2019). Phytochemical and Pharmacological Profile of Origanum sipyleum Extracts: Exploring Novel Sources for Potential Pharmaceutical, Food, and Cosmetic Applications. Planta Medica, 85, (18), P-361.
dc.identifier.doi10.1055/s-0039-3400071en_US
dc.identifier.endpage1542en_US
dc.identifier.issn0032-0943en_US
dc.identifier.issn1439-0221en_US
dc.identifier.issue18en_US
dc.identifier.startpage1542en_US
dc.identifier.urihttps://dx.doi.org/10.1055/s-0039-3400071
dc.identifier.urihttps://hdl.handle.net/20.500.12395/38105
dc.identifier.volume85en_US
dc.identifier.wosWOS:000503772900411en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.institutionauthorZengin, Gökhan
dc.language.isoenen_US
dc.publisherGeorg Thieme Verlag KGen_US
dc.relation.ispartofPlanta Medicaen_US
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectOriganum sipyleum
dc.subjectPhytochemica
dc.titlePhytochemical and Pharmacological Profile of Origanum Sipyleum Extracts: Exploring Novel Sources for Potential Pharmaceutical, Food, and Cosmetic Applicationsen_US
dc.typeConference Objecten_US

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