Kronik obstrüktif akciğer hastalığında teofilinin akım oran indeksi ve solunum fonksiyon testleri üzerine etkisi
Küçük Resim Yok
Tarih
1997
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Bu çalışma, kronik obstrüktif akciğer hastalığında (KOAH) tek doz intravenöz teofilinin bronkodilatör etkisini araştırmak için planlandı. Teofilinin bronkodilatör etkisini belirlemede standart solunum fonksiyon testlerinin yamsıra, akım-oran indeksi (FR 75) de incelendi. Çalışma, akut atak döneminde bulunan 42 KOAH'lı hasta üzerinde çift kör, plasebo kontrollü metodla gerçekleştirildi. 21 hastaya (yaş ortalaması 60.1 2.34) 6 mg/kg dozunda intravenöz teofılin uygulanırken, kontrol grubunu oluşturan 21 hastaya (yaş ortalaması 59.5 3.25) ise sadece serum fizyolojik enjekte edildi. İntravenöz enjeksiyonlardan önce ve 10 dakika sonrasında solunum fonksiyon testleri yaptırıldı ve akım-oran indeksleri hesaplandı. Teofılin uygulanan hastalarda FVC ve FR 75 haricindeki diğer tüm parametrelere ait bazale göre değişim oranları plaseboya göre önemli derecede yüksek bulundu. Böylece KOAFTın akut atak tedavisinde tek doz teofılin enjeksiyonunun uygulanabileceği sonucuna varıldı.
This study was designed to assess the bronchodila effect of single dose of intravenous theophylline chronic obstructive pulmonary disease (COPD' addition to the standard pulmonary function te the flow-ratio index (FR75) was also investige and included in this study. We conducted a rand< ized. placebo-controlled,double blind trial in patients at exacerbated state. Twenty-one patients (mean age, 60.1 ± 2.34 ye received 6 mg/kg of intravenous theophylline.w the remaining 21 patients (mean age. 59.5 ± : years) &#8226; xeived only intravenous seram physiok The pulmonary' function tests and flow-ratio ii were determined before and 10 minutes after intravenous injections. All pulmonary function rameters were significantly increased after t phylline administration. However, this increase in FVC and FR75) was signifcantly higher in 1 phylline group than in placebo group. Our fini suggest that, the single dose of intravenous 1 phylline could be used in acute COPD exact tions.
This study was designed to assess the bronchodila effect of single dose of intravenous theophylline chronic obstructive pulmonary disease (COPD' addition to the standard pulmonary function te the flow-ratio index (FR75) was also investige and included in this study. We conducted a rand< ized. placebo-controlled,double blind trial in patients at exacerbated state. Twenty-one patients (mean age, 60.1 ± 2.34 ye received 6 mg/kg of intravenous theophylline.w the remaining 21 patients (mean age. 59.5 ± : years) &#8226; xeived only intravenous seram physiok The pulmonary' function tests and flow-ratio ii were determined before and 10 minutes after intravenous injections. All pulmonary function rameters were significantly increased after t phylline administration. However, this increase in FVC and FR75) was signifcantly higher in 1 phylline group than in placebo group. Our fini suggest that, the single dose of intravenous 1 phylline could be used in acute COPD exact tions.
Açıklama
Anahtar Kelimeler
Kulak, Burun, Boğaz, Solunum Sistemi
Kaynak
Tüberküloz ve Toraks
WoS Q Değeri
Scopus Q Değeri
Cilt
45
Sayı
4
