THE IMPORTANCE OF SOLUBLE UROKINASE PLASMINOGEN ACTIVATOR RECEPTOR IN PATIENTS WITH ACUTE BRUCELLOSIS

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dc.contributor.authorDemir, Nazlim Aktug
dc.contributor.authorDagi, Hatice Turk
dc.contributor.authorFindik, Duygu
dc.contributor.authorSumer, Sua
dc.contributor.authorUral, Onur
dc.contributor.authorKolgelier, Servet
dc.date.accessioned2020-03-26T19:07:33Z
dc.date.available2020-03-26T19:07:33Z
dc.date.issued2015
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractObjective: Brucellosis is a common zoonotic infectious disease especially in Mediterranean countries. Inflammatory markers are elevated during the course of acute brucellosis. C-reactive protein (CRP) is the most commonly used biochemical marker in clinical practice. Soluble urokinase type plasminogen activator receptor (suPAR) is an interesting biomarker which has drawn attention recently. Purpose o f this study is to examine correlation between suPAR and CRP levels as markers o f infectious disease in patients diagnosed with acute brucellosis. Material and Method: This study included 125 acute brucellosis patients and 50 healthy controls. Pretreatment blood samples were taken from the patients. suPAR levels were measured using ELISA and CRP levels were measured with nephelometry. Results: There was a positive correlation between suPAR levels and CRP, alanine aminotransferase (ALT) and aspartate aminotransferase (AST) (p=0.045, 0.039, 0.040; respectively). When we compared patient and control groups, CRP and suPAR levels were significantly higher than controls (p=0.001, 0.001; respectively). Growth in blood culture was detected in 14 (11.2%) patients. Tlrere was not a significant difference between patients who have or did not have growth in blood cultures (p=0.117). In the ROC curve analysis performed for suPAR, area under the curve (AUC) was 93.6% (p=0.001). Sensitivity and specificity were calculated as 84.8% and 86.0%, respectively, when suPAR's cut-off value was taken as 3.85 ng/mL according to the ROC curve. Conclusion: Results of this study suggest that suPAR, like CRP, is a promising biomarker in acute brucellosis.en_US
dc.identifier.endpage91en_US
dc.identifier.issn1305-2381en_US
dc.identifier.issue1en_US
dc.identifier.pmid#YOKen_US
dc.identifier.startpage87en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12395/32661
dc.identifier.volume11en_US
dc.identifier.wosWOS:000373721600014en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherNOBEL ILACen_US
dc.relation.ispartofNOBEL MEDICUSen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectBrucellosisen_US
dc.subjectC-reactive proteinen_US
dc.subjectsoluble urokinase type plasminogen activator receptoren_US
dc.titleTHE IMPORTANCE OF SOLUBLE UROKINASE PLASMINOGEN ACTIVATOR RECEPTOR IN PATIENTS WITH ACUTE BRUCELLOSISen_US
dc.typeArticleen_US

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