Protective effects of vitamin E in experimentally induced rhabdomyolysis
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Dosyalar
Tarih
2013
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Selçuk Üniversitesi Veterinerlik Fakültesi
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Amaç: Ratlarda deneysel olarak oluşturulan rabdomiyoliz olgularında vitamin E uygulamasının koruyucu etkilerini değerlendirmektir. Gereç ve Yöntem: Yirmi bir adet rat üç eşit gruba ayrıldı: kontrol (Grup 1), gliserol (%50 gliserol, 7 mL/kg, IM) ve gliserol (%50 gliserol, 7 mL/kg, IM) + vitamin E grup (100 mg/ kg, IP, SID). Gliserol uygulamasından doksan altı saat sonra kan örnekleri alındı. Serumdan kreatinin, kan üre nitrojen, kreatin kinaz, aspartat aminotransferaz, alanin aminotransferaz ve laktat dehidrogenaz düzeyleri ölçüldü. Karaciğer ve böbrek dokusunun histopatalojik incelemesi yapıldı Bulgular: Gliserol + vitamin E grubu kreatinin, laktat dehidrogenaz ve kreatin kinaz düzeyleri gliserol grubundan düşük (p<0.05) belirlendi. Vitamin E uygulamasının gliserolün neden olduğu renal tübuler hasarı azalttığı tespit edildi. Öneriler: Vitamin E uygulamasının rabdomiyoliz vakalrında gözlenen renal ve kas hasarını azaltabileceği ifade edilebilir.
Aim: Evaluation of the protective effects of vitamin E administration in a rat model of rhabdomyolysis. Material and Method: Twenty one rats were divided to three equal groups; control (Group 1), glycerol (50% glycerol, 7 mL/kg, IM) and glycerol (50% glycerol, 7 mL/kg, IM) + Vitamin E (100 mg/kg, IP, SID). Ninety-six hours after glycerol injection, blood samples were collected. Serum creatinine, blood urea nitrogen, creatine kinase, aspartate aminotransferase, alanine aminotransferase and lactate dehydrogenase levels were measured. Histopathologic pattern of hepatic and renal tissue damages was also evaluated. Results: Glycerol + vitamin E groups had lower (P<0.05) creatinine, lactate dehydrogenase and creatine kinase levels than the glycerol group, and the administration of vitamin E caused lesser renal tubular damages in glycerol + vitamin E group rather than in glycerol group. Conclusions: Vitamin E administration may decrease the muscle injury and renal damage in rhabdomyolysis cases.
Aim: Evaluation of the protective effects of vitamin E administration in a rat model of rhabdomyolysis. Material and Method: Twenty one rats were divided to three equal groups; control (Group 1), glycerol (50% glycerol, 7 mL/kg, IM) and glycerol (50% glycerol, 7 mL/kg, IM) + Vitamin E (100 mg/kg, IP, SID). Ninety-six hours after glycerol injection, blood samples were collected. Serum creatinine, blood urea nitrogen, creatine kinase, aspartate aminotransferase, alanine aminotransferase and lactate dehydrogenase levels were measured. Histopathologic pattern of hepatic and renal tissue damages was also evaluated. Results: Glycerol + vitamin E groups had lower (P<0.05) creatinine, lactate dehydrogenase and creatine kinase levels than the glycerol group, and the administration of vitamin E caused lesser renal tubular damages in glycerol + vitamin E group rather than in glycerol group. Conclusions: Vitamin E administration may decrease the muscle injury and renal damage in rhabdomyolysis cases.
Açıklama
Anahtar Kelimeler
Vitamin E, böbrek hasarı, rabdomiyoliz, renal damages, rhabdomyolysis
Kaynak
Eurasian Journal Of Veterinary Sciences
WoS Q Değeri
Scopus Q Değeri
Cilt
29
Sayı
4
Künye
Tajik, J., Kheirandish, R., Rohani, H., Abbasi, A., (2013). Protective effects of vitamin E in experimentally induced rhabdomyolysis. Eurasian Journal of Veterinary Sciences, 29 (4), 180-184.
