Toxic Metal and Essential TraceElement Levels of Blood Donors
Küçük Resim Yok
Tarih
2016
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Amaç: Kan bağışı yapan bireyler hepatit, sitomegalovirüs gibi değişik patojenler açısından taranmaktadır. Toksik metal düzeylerinin taranması rutin bir prosedür değildir. Bu çalışmanın amacı, maruziyeti olmayan Türk bireylerde demir, çinko ve bakır gibi eser elementlerin ve kadmiyum, kurşun gibi toksik metallerin tam kan düzeylerini saptamak ve kronik metal toksisitesi riski bulunan bireyleri tanımlamaktır. Gereç ve Yöntem: Tam kan kurşun ve kadmiyum düzeyleri grafit fırınlı atomik absorpsiyon spectrometresi ile analiz edildi. Metal düzeyleri 211 erkek kan bağışı yapan bireyin (19-55 yaş arası, 33.718.69 yıl) tam kan ve serumlarında çalışıldı. İstatistiksel analiz SPSS v16 ile gerçekleştirildi. Bulgular: Kadmiyum, kurşun, çinko, bakır ve demir düzeylerinin ortalaması sırasıyla 1.270.88 µg L-1, 25.112.44 µg L-1, 0.970.16 mg L-1, 1.100.21 mg L-1, 476.5342.41 mg L-1 idi. Sadece bakır düzeyleri ile yaş arasında istatistiksel olarak anlamlı pozitif korelasyon saptandı (p0.01). Vücut kitle indeksi ve ölçülen tüm diğer metal seviyeleri arasında önemli bir korelasyon saaptanamadı (p0.05). Sigara içimi ile kadmiyum düzeyleri istatistiksel olarak anlamlı ilişki gözlendi (p0.01). Tartışma: Sonuçlar, toksikologlara ve klinik kimyacılara insanların eser element eksikliği veya daha yüksek metal seviyelerine maruziyet hakkında bilgi sağlayabilir.
Aim: Blood donors are screened for various pathogens including hepatitis and cytomegalovirus. Screening for toxic metal levels is not routine process. The aims of our study were to determine the whole blood levels of toxic metals, cadmium and lead, and levels of the trace elements iron, zinc, and copper, of non-exposed Turkish subjects and also to identify individuals living under the risk of chronic metal toxicity. Material and Method: Whole blood lead and cadmium levels were analyzed by Graphite Furnace Atomic Absorption Spectrometry. Metal levels were determined in the whole blood and serum samples of 211 male blood donors (aged 19 to 55; 33.71±8.69 years). Statistical analysis was performed by SPSSv16. Results: Average levels of cadmium, lead, zinc, copper and iron were found to be 1.27±0.88 µg L-1, 25.1±12.44 µg L-1, 0.97±0.16 mg L-1, 1.10±0.21 mg L-1, and 476.53±42.41 mg L-1, respectively. Donor age had a statistically significant positive correlation only with copper levels (p<0.01). There were not any significant correlations between BMI and any of the measured metal levels (p>0.05). A statistically significant association was found between smoking and cadmium levels (p<0.01). Discussion: Results may provide information for toxicologists and clinical chemists to determine whether people have trace element deficiencies or have been exposed to higher levels of toxic metals.
Aim: Blood donors are screened for various pathogens including hepatitis and cytomegalovirus. Screening for toxic metal levels is not routine process. The aims of our study were to determine the whole blood levels of toxic metals, cadmium and lead, and levels of the trace elements iron, zinc, and copper, of non-exposed Turkish subjects and also to identify individuals living under the risk of chronic metal toxicity. Material and Method: Whole blood lead and cadmium levels were analyzed by Graphite Furnace Atomic Absorption Spectrometry. Metal levels were determined in the whole blood and serum samples of 211 male blood donors (aged 19 to 55; 33.71±8.69 years). Statistical analysis was performed by SPSSv16. Results: Average levels of cadmium, lead, zinc, copper and iron were found to be 1.27±0.88 µg L-1, 25.1±12.44 µg L-1, 0.97±0.16 mg L-1, 1.10±0.21 mg L-1, and 476.53±42.41 mg L-1, respectively. Donor age had a statistically significant positive correlation only with copper levels (p<0.01). There were not any significant correlations between BMI and any of the measured metal levels (p>0.05). A statistically significant association was found between smoking and cadmium levels (p<0.01). Discussion: Results may provide information for toxicologists and clinical chemists to determine whether people have trace element deficiencies or have been exposed to higher levels of toxic metals.
Açıklama
Anahtar Kelimeler
Genel ve Dahili Tıp
Kaynak
Journal of Clinical and Analytical Medicine
WoS Q Değeri
Scopus Q Değeri
Cilt
7
Sayı
6
