Investigation of the metal bonding properties of fluoroquinolone type antibiotics using spectrofluorimetric method

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dc.contributor.authorBeniz Gündüz S.
dc.contributor.authorÇan S.
dc.contributor.authorÖzkan S.A.
dc.date.accessioned2020-03-26T19:08:23Z
dc.date.available2020-03-26T19:08:23Z
dc.date.issued2015
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractThe metal bonding properties of fluoroquinolone type antibiotics, namely levofloxacin and ciprofloxacin, were investigated by using spectrofluorimetric method. Fluorescence quenching of levofloxacin (LEV) and ciprofloxacin (CIP) by Fe (III) has been studied. The optimal experimental conditions were determined. The excitation and emission wavelengths were ?ex= 390 nm and ?em= 500 nm for the Fe (III)-LEV complex and ?ex= 370 nm and ?em= 462 nm for the Fe(III)-CIP complex at pH 5.5 in water medium. The calibration curves were obtained from Stern- Volmer equation plotting to F0/F-[Fe+3] graphs and the linearity was found within the range of 0.056-0.56 ?g.mL-1 for the Fe(III)-LEV complex and 0.56-5.58 ?g.mL-1 for the Fe(III)-CIP complex under the optimal conditions. The detection limits (LOD) of the proposed method for the Fe(III)-LEV and Fe(III)-CIP complexes were 1.6 ng.mL-1 and 5.9 ng.mL-1 respectively and the quantitation limits (LOQ) of these complexes were found to be 5.3 ng.mL-1 and 19.7 ng.mL-1 respectively. The stochiometry of both complexes was also determined by using the continuous variation method and the molar ratio of Fe(III):Fluoroquinolone was calculated as 2:3. The interaction between the fluoroquinolones in tablet forms and Fe(III) in the vitamin-mineral combination tablet was investigated by applying this quenching method and obtained satisfactory results. © 2014 Bentham Science Publishers.en_US
dc.identifier.doi10.2174/1574885510999150505165011en_US
dc.identifier.endpage269en_US
dc.identifier.issn1574-8855en_US
dc.identifier.issue4en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage261en_US
dc.identifier.urihttps://dx.doi.org/10.2174/1574885510999150505165011
dc.identifier.urihttps://hdl.handle.net/20.500.12395/32834
dc.identifier.volume9en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherBentham Science Publishers B.V.en_US
dc.relation.ispartofCurrent Drug Therapyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectCiprofloxacinen_US
dc.subjectFe(III) complexen_US
dc.subjectFluorescence quenchingen_US
dc.subjectLevofloxacinen_US
dc.subjectPharmaceutical analysisen_US
dc.titleInvestigation of the metal bonding properties of fluoroquinolone type antibiotics using spectrofluorimetric methoden_US
dc.typeArticleen_US

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