The favorable effects of vitamine e added on treatment of experimental acute organic phosphorus toxicity [Deneysel akut organik fosfor toksisitesi tedavisine eklenen e vitaminin olumlu etkileri]

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dc.contributor.authorBayir A.
dc.contributor.authorYildiz M.
dc.contributor.authorKara H.
dc.contributor.authorKöylü O.
dc.contributor.authorKocabaş R.
dc.contributor.authorAk A.
dc.date.accessioned2020-03-26T18:22:05Z
dc.date.available2020-03-26T18:22:05Z
dc.date.issued2011
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractObjectives: Oxidative stress by increased production of reactive oxygen species has been implicated in the toxicity of many pesticides. The tissue levels of ROS are one of the most important indicator of tissue injury. The aim of this study was to examine the effects of vitamin E treatment in acute organophosphate poisoning (AOP) on choline esterase (CE) and Malondialdehit (MDA) levels in the liver tissue and blood and to compare with antidote treatment. Methods: Twenty New Zaeland type rabbits were divided into randomly three groups as sham (n=8), pralidoxime (PAM)+atropine (n=6), and vitamin E (n=6). blood samples were taken from each test subjects to measure plasma CE, serum and erythrocyte MDA values before toxicity. 50 mg/kg 2,2-dichlorovinyl dimethyl phosphate were given to all subjects orogastrically. The PAM-atropine group were given 30 mg/kg IV bolus, then 15 mg/kg PAM and 0.05 mg/kg atropine IV every 4 hours. The vitamin E group received 250 mg/kg vitamin E single dose IM in addition to same atropine and PAM treatment. Blood samples were obtained from the all subjects in the 12th and 24th hours followed by the initiation of treatment. The liver tissue samples were obtained to evaluate in order to evaluate same parameters. The test subjects were sacrificed by high dose IV anesthesia. Results: The erythrocyte MDA of vitamin E group was significantly lower than PAM-atropine group (p=0.003). Liver tissue CE level of vitamin E group was considerably higher than PAM-atropine group (p<0.001). Liver tissue MDA of vitamin E group was significantly lower than PAMatropine group (p<0.001). Conclusions: Included in the treatment of acute AOF toxicity, vitamin E has a curative effect on both erythrocyte and liver tissue lipid peroxidation and tissue CE activity.en_US
dc.identifier.doi10.5505/1304.7361.2011.26986en_US
dc.identifier.endpage48en_US
dc.identifier.issn1304-7361en_US
dc.identifier.issue2en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage42en_US
dc.identifier.urihttps://dx.doi.org/10.5505/1304.7361.2011.26986
dc.identifier.urihttps://hdl.handle.net/20.500.12395/27137
dc.identifier.volume11en_US
dc.indekslendigikaynakScopusen_US
dc.language.isotren_US
dc.relation.ispartofTurkiye Acil Tip Dergisien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectcholinesteraseen_US
dc.subjectMalondialdehydeen_US
dc.subjectOrganophosphorusen_US
dc.subjectOximeen_US
dc.subjectVitamin Een_US
dc.titleThe favorable effects of vitamine e added on treatment of experimental acute organic phosphorus toxicity [Deneysel akut organik fosfor toksisitesi tedavisine eklenen e vitaminin olumlu etkileri]en_US
dc.typeArticleen_US

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