Y Chromosome Microdeletions in Turkish Infertile Men

Basit Öğe Kaydı
dc.contributor.authorZamani, Ayşe Gül
dc.contributor.authorKutlu, R.
dc.contributor.authorDurakbaşı, Gül
dc.contributor.authorGörkemli, H.
dc.contributor.authorAcar, A.
dc.contributor.authorDursun, H.
dc.date.accessioned2020-03-26T17:05:42Z
dc.date.available2020-03-26T17:05:42Z
dc.date.issued2006
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractAIMS: To detect the frequency and types of both chromosomal abnormalities and Y chromosome microdeletions in infertile men attending to our university intracytoplasmic sperm injection ICSI/IVF centre and fertile control subjects in our patient population. SETTINGS AND DESIGN: A total of 50 infertile men who were referred to IVF center of Meram medical faculty were selected for the molecular azospermia factor (AZF) screening program. MATERIALS AND METHODS: Karyotype analysis and polymerase chain reaction amplification using 15 Y-specific sequence-tagged sites of AZF region were done. RESULTS: The total prevalence of chromosomal abnormalities was found to be 10% (5/50), including 4 patients with numerical and 1 patient with structural abnormalities. Overall, 4 of the 50 patients tested (8%) exhibited deletions of the Y chromosome, 3 of them being azospermic and 1 of them oligospermic men. The frequency of the microdeletions in subgroups with azospermia and oligozoospermia was found to be 10.7% (3/29) and 4.7% (1/21) respectively. Microdeletions of AZFb and AZFc regions were detected in all of the 4 patients. Neither AZFa nor AZFd microdeletions were indicated. CONCLUSIONS: Our findings suggest that one must know whether there is a genetic cause for male infertility before patients can be subjected to ISCI or testicular sperm extraction (TESE)/ISCI treatment.en_US
dc.identifier.citationZamani, A. G., Kutlu, R., Durakbaşı, G., Görkemli, H., Acar, A., Dursun, H., (2006). Y Chromosome Microdeletions in Turkish Infertile Men. Indian Journal of Human Genetics, 12(1), 66-71.
dc.identifier.endpage71en_US
dc.identifier.issn0971-6866en_US
dc.identifier.issue2en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage66en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12395/20951
dc.identifier.volume12en_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorZamani, Ayşe Gül
dc.language.isoenen_US
dc.relation.ispartofIndian Journal of Human Geneticsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectAZF regionen_US
dc.subjectAzospermiaen_US
dc.subjectChromosomal abnormalityen_US
dc.subjectMale infertilityen_US
dc.subjectOligozoospermiaen_US
dc.subjectY-chromosomeen_US
dc.titleY Chromosome Microdeletions in Turkish Infertile Menen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

Scopus İndeksli Yayınlar Koleksiyonu
Tıbbi Genetik/Makale Koleksiyonu