Sperm Chromatin Dynamics Associated with Male Fertility in Mammals

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dc.contributor.authorKutchy N.A.
dc.contributor.authorDogan S.
dc.contributor.authorKaya A.
dc.contributor.authorMoura A.
dc.contributor.authorMemili E.
dc.date.accessioned2020-03-26T19:44:00Z
dc.date.available2020-03-26T19:44:00Z
dc.date.issued2017
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractInstead of two protamines (PRM1 and PRM2) as in human and mouse sperms, presence of only PRM1 in bull sperm raises an interesting question about the mechanism(s) regulating sperm chromatin structure. During spermatogenesis, spermatozoa that are present in syncytium share mRNA and proteins through cytoplasmic bridges and are phenotypically diploid. Chromatin remodeling occurs during spermatogenesis where linker histones are gradually replaced by testis-specific variants, followed by the replacement of histones with transition proteins and then with protamines. Increased percentage of histone retention is expected to cause infertility in males. Although protamines are involved in sperm chromatin condensation and function, there is restrictive positive selection on only a few functional sites. Improper packaging of sperm DNA caused partly by reduced protamination predisposes sperm DNA to damage, which then interferes with fertilization and early embryonic development. Abnormal chromatin condensation in sperm during spermatogenesis and abnormal chromatin decondensation during pronucleus formation (postfertilization) can result in reproductive problems. © 2017 by John Wiley & Sons, Inc. All rights reserved.en_US
dc.identifier.doi10.1002/9781118881286.ch16en_US
dc.identifier.endpage434en_US
dc.identifier.isbn9781118881286; 9781118881606
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage427en_US
dc.identifier.urihttps://dx.doi.org/10.1002/9781118881286.ch16
dc.identifier.urihttps://hdl.handle.net/20.500.12395/35799
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherwileyen_US
dc.relation.ispartofAnimal Models and Human Reproductionen_US
dc.relation.publicationcategoryKitap Bölümü - Uluslararasıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectAbnormal chromatin condensationen_US
dc.subjectFemale reproductive tracten_US
dc.subjectFunctional spermatozoaen_US
dc.subjectMale fertilityen_US
dc.subjectMammalsen_US
dc.subjectPrefertilization eventen_US
dc.subjectProtamination predisposes sperm DNAen_US
dc.subjectSperm chromatin dynamicsen_US
dc.subjectTransition proteinsen_US
dc.titleSperm Chromatin Dynamics Associated with Male Fertility in Mammalsen_US
dc.typeBook Chapteren_US

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