Kan kültürlerinden izole edilen acinetobacter baumannii suşlarında antibiyotik direnci
Küçük Resim Yok
Tarih
2011
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Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Acinetobacter baumannii suşlarında sık kullanılan antibiyotiklere karşı oluşan yüksek direnç oranları tedavi seçeneklerini sınırlamaktadır. Bu çalışmanın amacı, hastanemizde yatan hastaların kan kültürlerinden izole edilen A.baumannii izolatlarının çeşitli antibiyotiklere direncinin belirlenmesidir. Çalışmada 2008-2009 yıllarında kan kültürlerinden izole edilen 224 A.baumannii suşunun antibiyotiklere direnci retrospektif olarak incelenmiştir. Bakteri identifikasyonu konvansiyonel yöntemler ve Phoenix 100 BD otomatize sistemi (Becton Dickinson Diagnostic Systems, Sparks) kullanılarak yapılmıştır. Bakterilerin antibiyotiklere duyarlılıkları, Clinical Laboratory Standards Institute (CLSI) önerileri dikkate alınarak Kirby-Bauer disk difüzyon yöntemi ile saptanmıştır. Suşlarda kolistine direnç saptanmamış, amikasine % 59, tetrasikline % 67, imipenem, sefoperazon-sulbaktam ve siprofloksasine % 75, gentamisine % 79, seftazidime % 80, piperasilin-tazobaktama % 81, sefepime % 86 ve sefotaksime % 96 oranında direnç saptanmıştır. Kolistin ve amikasinin diğer antibiyotiklere göre daha etkili olduğu belirlenmiştir. Sonuç olarak, özellikle ampirik tedavi gerektiren durumlarda bu tür dirençli bakterilerin duyarlılık oranlarının bilinmesi gereklidir.
Due to high resistance in Acinetobacter baumannii strains against commonly administered antibiotics, the treatment of their infections is becoming difficult. This study aims to determine the antibiotic resistance of Acinetobacter baumannii strains isolated from bloodstream infections in our hospital. Antibiotic resistance of 224 A.baumannii strains isolated from blood cultures in 2008-2009 were assessed retrospectively. The isolates were identified by conventional methods and Phoenix 100 BD automated system (Becton Dickinson Diagnostic Systems, Sparks). Antibiotic susceptibility tests were performed by the Kirby-Bauer disk-diffusion method according to the standards of Clinical and Laboratory Standards Institute (CLSI). Colistin resistance was not determined. The antibiotic resistance rates of the strains were found to be 59 % for amikacin, 67 % for tetracycline, 75 % for imipenem, cefoperazone-sulbactam and ciprofloxacin, 79 % for gentamicin, 80 % for ceftazidime, 81 % for piperacillin-tazobactam, 86 % for cefepime and 96 % for cefotaxime. The results indicate that colistin and amikacin are more active agents than other antibiotics. In conclusion, susceptibility rates of such resistant bacteria should be known especially in situations where empirical treatment is required.
Due to high resistance in Acinetobacter baumannii strains against commonly administered antibiotics, the treatment of their infections is becoming difficult. This study aims to determine the antibiotic resistance of Acinetobacter baumannii strains isolated from bloodstream infections in our hospital. Antibiotic resistance of 224 A.baumannii strains isolated from blood cultures in 2008-2009 were assessed retrospectively. The isolates were identified by conventional methods and Phoenix 100 BD automated system (Becton Dickinson Diagnostic Systems, Sparks). Antibiotic susceptibility tests were performed by the Kirby-Bauer disk-diffusion method according to the standards of Clinical and Laboratory Standards Institute (CLSI). Colistin resistance was not determined. The antibiotic resistance rates of the strains were found to be 59 % for amikacin, 67 % for tetracycline, 75 % for imipenem, cefoperazone-sulbactam and ciprofloxacin, 79 % for gentamicin, 80 % for ceftazidime, 81 % for piperacillin-tazobactam, 86 % for cefepime and 96 % for cefotaxime. The results indicate that colistin and amikacin are more active agents than other antibiotics. In conclusion, susceptibility rates of such resistant bacteria should be known especially in situations where empirical treatment is required.
Açıklama
Anahtar Kelimeler
Farmakoloji ve Eczacılık
Kaynak
ANKEM Dergisi
WoS Q Değeri
Scopus Q Değeri
Cilt
25
Sayı
1
