CYTOTOXIC AND ANTIVIRAL ACTIVITY OF RIBES UVA CRISPA LINN. AND RIBES MULTIFLORUM KIT. EX ROMER AND SCHULTES EXTRACTS

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dc.contributor.authorDuman, Rustem
dc.contributor.authorDogan, Hasan Huseyin
dc.contributor.authorDinc, Muhittin
dc.contributor.authorTuncer, Pinar
dc.date.accessioned2020-03-26T19:53:16Z
dc.date.available2020-03-26T19:53:16Z
dc.date.issued2018
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractTo find new antiviral agents from natural sources, methanol and aqueous extracts of leaves and fruits of Ribes uva crispa and Ribes multiflorum naturally grown in Turkey were investigated as in vitro to reveal their antiviral activities against Herpes simplex virus type 1. All experiments were performed in 96-well plates and results were measured with XTT-based colorimetric assay. Results demonstrated that all extracts have no cytotoxic effect on vero cells at 10000 mu g/mL, while they also exhibited anti-HSV-1 activity with different percentages of protection (varying between 2.65% - 50.40%) in 10000 mu g/mL which was at the highest concentration in vero cells. 50% effective concentrations (EC50) of the extracts which were determined having percentage of protection against HSV-1 at concentrations lower than 10000 mu g/mL were calculated using GraphPad Prism Version 5.03 statistics program with non-linear regression analysis. These extracts were determined to have EC50 values ranging between 9710 - 70600 mu g/mL and selectivity index (SI) are ranging between 0.14 - 1.03. On the basis of these results we believe that it would be worthwhile expanding these studies to include additional species of Turkish plants.en_US
dc.description.sponsorshipSelcuk University, Scientific Research Projects Coordinating OfficeSelcuk University [SU-BAP-14401088]en_US
dc.description.sponsorshipThe authors would like to thank Selcuk University, Scientific Research Projects Coordinating Office (SU-BAP-14401088) for the project funding.en_US
dc.identifier.doi10.13040/IJPSR.0975-8232.9(5).1779-87en_US
dc.identifier.endpage1787en_US
dc.identifier.issn0975-8232en_US
dc.identifier.issue5en_US
dc.identifier.pmid#YOKen_US
dc.identifier.startpage1779en_US
dc.identifier.urihttps://dx.doi.org/10.13040/IJPSR.0975-8232.9(5).1779-87
dc.identifier.urihttps://hdl.handle.net/20.500.12395/36455
dc.identifier.volume9en_US
dc.identifier.wosWOS:000434060800006en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherINT JOURNAL PHARMACEUTICAL SCIENCES & RESEARCHen_US
dc.relation.ispartofINTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES AND RESEARCHen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectAnti-HSV-1 activityen_US
dc.subjectNatural plant extractsen_US
dc.subjectVero Cellsen_US
dc.subjectXTT methoden_US
dc.titleCYTOTOXIC AND ANTIVIRAL ACTIVITY OF RIBES UVA CRISPA LINN. AND RIBES MULTIFLORUM KIT. EX ROMER AND SCHULTES EXTRACTSen_US
dc.typeArticleen_US

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