Hypokalemic paralysis due to thyrotoxicosis accompanied by Gitelman's syndrome
Küçük Resim Yok
Tarih
2015
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Medknow Publications
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
A 35-year-old male patient was admitted with fatigue and muscle weakness. He had been on methimazole due to thyrotoxicosis for 2 weeks. Laboratory tests showed overt hyperthyroidism and hypokalemia. Potassium replacement was started with an initial diagnosis of thyrotoxic hypokalemic periodic paralysis. Later on, despite the euthyroid condition and potassium chloride treatment, hypokalemia persisted. Further investigations revealed hyperreninemic hyperaldosteronism. The patient was considered to have Gitelman's syndrome (GS) and all genetic analysis was done. A c. 1145C>T, p.Thr382Met homozygote missense mutation located on solute carrier family 12, member gene 3, exon 9 was detected and GS was confirmed.
Açıklama
Anahtar Kelimeler
Gitelman's syndrome, hypokalemic paralysis, thyrotoxicosis
Kaynak
Indian Journal of Nephrology
WoS Q Değeri
Scopus Q Değeri
Q3
Cilt
25
Sayı
2
