Anti-cyclic citrullinated peptide antibodies in rheumatoid arthritis, brucellar arthritis and Behcet's disease

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dc.contributor.authorAridogan, Buket Cicioglu
dc.contributor.authorCetin, Emel Sesli
dc.contributor.authorYildirim, Mehmet
dc.contributor.authorKaya, Selcuk
dc.contributor.authorCeyhan, Ali Murat
dc.contributor.authorDemirci, Mustafa
dc.contributor.authorSavas, Serpil
dc.date.accessioned2020-03-26T18:13:46Z
dc.date.available2020-03-26T18:13:46Z
dc.date.issued2011
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractIn Behcet's disease (BD) and Brucellosis, joint involvement is very common and it may share similarities with rheumatoid arthritis (RA). Anti-cyclic citrullinated peptides (CCP) are evaluated as more specific autoantibodies than rheumatoid factor (RF) in RA. The aim of this study is to determine whether anti-CCP antibodies are useful in the differential diagnosis of RA from other arthritis or not. 153 serum samples were used in the study; 34 from RA patients, 26 from brucellar arthritis, 20 from BD with arthritis, 41 from BD without arthritis and 32 from healthy controls. In vitro quantitative, anti-CCP levels were measured by using fluoroenzyme-immunoassay (FEIA) method. Among RA patients, 73.5% were anti-CCP-positive and 70.5% were RF-positive. While there was a statistical difference in the anti-CCP and RF positivity rates between RA and brucellar arthritis patients, BD patients and healthy controls (p = 0.0001), there was no statistical difference between BD patients with arthritis and BD patients without arthritis. Also none of the Brucellar arthritis patients was positive for anti-CCP antibodies, one of them were positive for RF. Our results indicate that anti-CCP antibodies are not associated with brucellar arthritis or BD with joint involvement and since they show high specificity and good sensitivity for RA, they can be evaluated as a better marker than RF especially for the differentiation of RA from other types of arthritis such as BD and brucellar arthritis.en_US
dc.identifier.endpage2979en_US
dc.identifier.issn1996-0808en_US
dc.identifier.issue19en_US
dc.identifier.startpage2975en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12395/26143
dc.identifier.volume5en_US
dc.identifier.wosWOS:000298919700018en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherACADEMIC JOURNALSen_US
dc.relation.ispartofAFRICAN JOURNAL OF MICROBIOLOGY RESEARCHen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectRheumatoid arthritisen_US
dc.subjectBehcet's diseaseen_US
dc.subjectbrucellar arthritisen_US
dc.subjectanti-cyclic citrullinated peptide antibodyen_US
dc.subjectrheumatoid factoren_US
dc.titleAnti-cyclic citrullinated peptide antibodies in rheumatoid arthritis, brucellar arthritis and Behcet's diseaseen_US
dc.typeArticleen_US

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