Inclusion of Quercetin in Gold Nanoparticles Decorated with Supramolecular Hosts Amplifies Its Tumor Targeting Properties

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dc.contributor.authorYilmaz M.
dc.contributor.authorKaranastasis A.A.
dc.contributor.authorChatziathanasiadou M.V.
dc.contributor.authorOguz M.
dc.contributor.authorKougioumtzi A.
dc.contributor.authorClemente N.
dc.contributor.authorKellici T.F.
dc.date.accessioned2020-03-26T20:19:55Z
dc.date.available2020-03-26T20:19:55Z
dc.date.issued2019
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractDespite the anticancer potential of natural products (NPs), their limited bioavailability necessitates laborious derivatization or covalent conjugation to delivery vehicles. To unleash their potential, we developed a nanohybrid delivery platform with a noncovalently tunable surface. Initially, the active compound was encapsulated in a macrocycle, p-sulfonatocalix[4]arene, enabling a 62â000-fold aqueous solubility amplification as also a 2.9-fold enhancement in its cytotoxicity with respect to the parent compound in SW-620 colon cancer cells. A pH stimuli responsive behavior was recorded for this formulate, where a programmable release of quercetin from the macrocycle was monitored in an acidic environment. Then, a nanoparticle gold core was decorated with calixarene hosts to accommodate noncovalently NPs. The loaded nanocarrier with the NP quercetin dramatically enhanced the cytotoxicity (>50-fold) of the parent NP in colon cancer and altered its cell membrane transport mode. In vivo experiments in a mouse 4T1 tumor model showed a reduction of tumor volume in mice treated with quercetin-loaded nanoparticles without apparent toxic effects. Further analysis of the tumor-derived RNA highlighted that treatment with quercetin-loaded nanoparticles altered the expression of 27 genes related to apoptosis. © 2019 American Chemical Society.en_US
dc.description.sponsorship17201066 General Secretariat for Research and Technology Hellenic Foundation for Research and Innovation: IKYDA2015, 20152002, 1090 European Commission 113Z445 Türkiye Bilimsel ve Teknolojik AraÅŸtirma Kurumu General Secretariat for Research and Technology Hellenic Foundation for Research and Innovation Research Promotion Foundation European Regional Development Funden_US
dc.description.sponsorshipWe would like to thank the Scientific and Technological Research Council of Turkey (TUBITAK grant no. 113Z445) and the Research Foundation of Selcuk University (BAP grant no. 17201066) for partial financial support of Mehmet Oguz’s Ph.D. thesis. This research has been cofinanced by the European Union (European Regional Development Fund, ETPA) and Greek national funds through the Operational Program Competitiveness and Entrepreneurship (OPCE II), Joint Research and Technology programs Bilateral Greece–Turkey 2013–2014. This research has been financially supported by the General Secretariat for Research and Technology (GSRT) and the Hellenic Foundation for Research and Innovation (HFRI) (scholarship code: 1090). This work was supported by the CERIC funded program (proposal no. 20152002), program for the promotion of the exchange and scientific cooperation between Greece and Germany IKYDA2015, and by the Cy-Tera Project, which is cofunded by the European Regional Development Fund and the Republic of Cyprus through the Research Promotion Foundation. We thank the confocal laser microscope facility of the Foundation for Research & Technology-Hellas, Institute of Molecular Biology and Biotechnology, Department of Biomedical Research, Ioannina, for the use of the Leica SP5 scanning confocal microscope. We thank Dr. Carol Murphy for fruitful discussions, comments and insightful corrections on the manuscript. We thank Sophia Kiriakidi for assistance in reformatting the image on the revised version of the manuscript. We thank Dr. Asif A. Bhatti for participating at the onset of the project.en_US
dc.identifier.doi10.1021/acsabm.8b00748en_US
dc.identifier.endpage2725en_US
dc.identifier.issn2576-6422en_US
dc.identifier.issue7en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage2715en_US
dc.identifier.urihttps://dx.doi.org/10.1021/acsabm.8b00748
dc.identifier.urihttps://hdl.handle.net/20.500.12395/38449
dc.identifier.volume2en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherAmerican Chemical Societyen_US
dc.relation.ispartofACS Applied Bio Materialsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectantitumor agentsen_US
dc.subjectcalixareneen_US
dc.subjectcanceren_US
dc.subjectdrug deliveryen_US
dc.subjectIn vivoen_US
dc.subjectnanoparticlesen_US
dc.subjectnatural productsen_US
dc.subjectquercetinen_US
dc.titleInclusion of Quercetin in Gold Nanoparticles Decorated with Supramolecular Hosts Amplifies Its Tumor Targeting Propertiesen_US
dc.typeArticleen_US

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