The development of forced degradation studies for the determination of daptomycin in urine at various conditions by using RP-LC method

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dc.authorid0000-0002-6652-4574
dc.authorid0000-0001-5469-9142
dc.authorid0000-0003-2414-9478
dc.authorid0000-0001-7494-3077
dc.contributor.authorAkmeşe, Bediha
dc.contributor.authorBakırhan, Nurgül K.
dc.contributor.authorGöver, Tuğçe
dc.contributor.authorÖzkan, Sibel A.
dc.date.accessioned2020-03-26T20:19:23Z
dc.date.available2020-03-26T20:19:23Z
dc.date.issued2019
dc.departmentSelçuk Üniversitesi, Eczacılık Fakültesi, Temel Eczacılık Bilimleri Bölümüen_US
dc.description.abstractDaptomycin is known as the first lipopeptide antibiotic shows activity against gram-positive bacteria. A fast, simple and repeatabile RP-LC method has been developed for the determination of daptomycin in mobile phase solution and human urine. This drug was exposed to various stress conditions such as hydrolytic, oxidative, thermal and photolytic and the stressed samples were detected by the proposed method. Daptomycin was well separated on a X-Terra RP-18 column using the mobile phase consisting of a mixture of acetonitrile: water (45:55 v/v) at a flow rate of 1 mL min(-1). The system operates at 222 nm for daptomycin and 319 nm and tinidazole was used as internal standard under these conditions. The linearity of daptomycin was obtained between 0.50 and 12 mu g mL(-1) concentration range. Limits of detection was determined as 0.1176 and 0.1412 mu g mL(-1) and the limits of quantification was obtained as 0.3563 and 0.4277 mu g mL(-1) in the mobile phase and urine, respectively. Hydrochloric acid, sodium hydroxide, hydrogen peroxide affected response of daptomycin under stress degradation conditions.en_US
dc.identifier.citationAkmeşe, B., Nurgül, K. B., Göver, T., Özkan, S. A. (2019). The Development of Forced Degradation Studies for the Determination of Daptomycin in Urine at Various Conditions by Using RP-LC Method. Journal of Research in Pharmacy, 23(2), 170-176.
dc.identifier.doi10.12991/jrp.2019.122en_US
dc.identifier.endpage176en_US
dc.identifier.issn2630-6344en_US
dc.identifier.issue2en_US
dc.identifier.pmid#YOKen_US
dc.identifier.startpage170en_US
dc.identifier.urihttps://dx.doi.org/10.12991/jrp.2019.122
dc.identifier.urihttps://hdl.handle.net/20.500.12395/38241
dc.identifier.volume23en_US
dc.identifier.wosWOS:000459615300003en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.institutionauthorGöver, Tuğçe.
dc.language.isoenen_US
dc.publisherMARMARA UNIVen_US
dc.relation.ispartofJOURNAL OF RESEARCH IN PHARMACYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectDrugen_US
dc.subjectdaptomycinen_US
dc.subjectdegradation conditionsen_US
dc.subjecthigh performance liquid chromatographyen_US
dc.titleThe development of forced degradation studies for the determination of daptomycin in urine at various conditions by using RP-LC methoden_US
dc.typeArticleen_US

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