Investigation of Some Biochemical Parameters in Bitches with Malignant Mammary Tumors
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Dosyalar
Tarih
2023 Mart
Yazarlar
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Yayıncı
Selçuk Üniversitesi
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Amaç: Bu çalışmada, meme tümörü olan dişi köpeklerde biyokimyasal parametrelerin cut-off değeri belirlenerek teşhis için biyobelirteç olarak kullanılabilirliği araştırıldı. Gereç ve Yöntem: Kliniğimize rutin ovariohisterektomi için getirilen (kontrol grubu, n = 14) ve meme tümörü olan (CMT grubu, n = 14) dişi köpekler çalışmaya dahil edildi. Biyokimyasal parametrelerden albümin (ALB), alkalin fosfataz (ALP), alanin aminotransferaz (ALT), aspartat aminotransferaz (AST), gama-glutamiltransferaz (GGT), total protein (TP), direkt bilirubin (DB), total bilirubin (TB), kreatin, kreatin kinaz-N-asetil-sistein (CK-NAK), üre, fosfor (P), magnezyum (Mg) ve kalsiyum (Ca) düzeyleri otomatik bir biyokimya analizör ile ölçüldü. Bulgular: ALP (p: 0,048), ALT (p < 0,000), AST (p: 0,043), GGT (p: 0,013), TP (p: 0,010), DB (p: 0,043), TB (p: 0,018), kreatin (p < 0,000), P (p < 0,000) ve CK-NAC (p < 0.000) düzeyleri CMT grubunda kontrol grubuna göre daha yüksek anlamlı bulundu. Mg (p < 0,000) düzeyi kontrol grubunda daha yüksek olmasına rağmen, gruplar arasında ALB, üre ve Ca düzeyleri için istatistiksel olarak fark bulunmadı (p > 0,05). ALP, ALT, AST, GGT, TP ve kreatin düzeylerinin, sırasıyla 0.656, 0.831, 0.610, 0.792, 0.942 ve 0.974 eğri altında kalan alan değerleri ile meme tümörlerinin teşhisi için kullanılabileceği görüldü. Öneri: ALP, ALT, AST, GGT, TP ve kreatinin köpek meme tümörü için yardımcı tanı araçları olabileceği kanısına varıldı.
Aim: This study, the cut-off point of biochemical parameters in bitches with mammary tumors was determined and its usability as a biomarker for diagnosis was investigated. Materials and Methods: Bitches that presented to our clinic for routine ovariohysterectomy (control group, n = 14) and suffer from mammary tumors (CMT group, n = 14) were included in the study. Biochemical parameters including albümin (ALB), alkaline phosphatase (ALP), alanine aminotransferase (ALT), aspartate aminotransferase (AST), gammaglutamyltransferase (GGT), total protein (TP), direct bilirubin (DB), total bilirubin (TP), creatine, creatine kinase-N-acetyl-cysteine (CK-NAC), urea, phosphorus (P), magnesium (Mg), and calcium (Ca) concentrations were measured with an automated chemistry analyzer. Results: The ALP (p: 0.048), ALT (p < 0.000), AST (p: 0.043), GGT (p: 0.013), TP (p: 0.010), DB (p: 0.043), TP (p: 0.018), creatine (p < 0.000), P (p < 0.000), and CK-NAC (p < 0.000) concentrations were found to be higher in the CMT group than in the control group. Although Mg (p < 0.000) concentration was higher in the control group, there was no statistical significance for ALB, urea, and Ca concentrations among the groups (p > 0.05). It was seen that ALP, ALT, AST, GGT, TP, and creatine concentrations could be used to diagnose mammary tumors, with area under the curve (AUC) values of 0.656, 0.831, 0.610, 0.792, 0.942, and 0.974, respectively. Conclusion: It was concluded that ALP, ALT, AST, GGT, TP, and creatine could be helpful diagnostic tools for canine mammary tumors.
Aim: This study, the cut-off point of biochemical parameters in bitches with mammary tumors was determined and its usability as a biomarker for diagnosis was investigated. Materials and Methods: Bitches that presented to our clinic for routine ovariohysterectomy (control group, n = 14) and suffer from mammary tumors (CMT group, n = 14) were included in the study. Biochemical parameters including albümin (ALB), alkaline phosphatase (ALP), alanine aminotransferase (ALT), aspartate aminotransferase (AST), gammaglutamyltransferase (GGT), total protein (TP), direct bilirubin (DB), total bilirubin (TP), creatine, creatine kinase-N-acetyl-cysteine (CK-NAC), urea, phosphorus (P), magnesium (Mg), and calcium (Ca) concentrations were measured with an automated chemistry analyzer. Results: The ALP (p: 0.048), ALT (p < 0.000), AST (p: 0.043), GGT (p: 0.013), TP (p: 0.010), DB (p: 0.043), TP (p: 0.018), creatine (p < 0.000), P (p < 0.000), and CK-NAC (p < 0.000) concentrations were found to be higher in the CMT group than in the control group. Although Mg (p < 0.000) concentration was higher in the control group, there was no statistical significance for ALB, urea, and Ca concentrations among the groups (p > 0.05). It was seen that ALP, ALT, AST, GGT, TP, and creatine concentrations could be used to diagnose mammary tumors, with area under the curve (AUC) values of 0.656, 0.831, 0.610, 0.792, 0.942, and 0.974, respectively. Conclusion: It was concluded that ALP, ALT, AST, GGT, TP, and creatine could be helpful diagnostic tools for canine mammary tumors.
Açıklama
Anahtar Kelimeler
Biyokimyasal parametreler, köpek, meme tümörleri, Biochemical parameters, bitch, mammary tumors
Kaynak
Eurasian Journal of Veterinary Sciences
WoS Q Değeri
Scopus Q Değeri
Cilt
39
Sayı
1
Künye
Safak, T., (2023). Investigation of Some Biochemical Parameters in Bitches with Malignant Mammary Tumors. Eurasian Journal of Veterinary Sciences, 39(1), 18-24.
DOI: 10.15312/EurasianJVetSci.2023.394
