Repeated supramaximal exercise-induced oxidative stress: Effect of ?-Alanine plus creatine supplementation

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dc.contributor.authorBelviranli M.
dc.contributor.authorOkudan N.
dc.contributor.authorRevan S.
dc.contributor.authorBalci S.
dc.contributor.authorGokbel H.
dc.date.accessioned2020-03-26T19:32:04Z
dc.date.available2020-03-26T19:32:04Z
dc.date.issued2016
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractBackground: Carnosine is a dipeptide formed from the ?-alanine and histidine amino acids and found in mainly in the brain and muscle, especially fast twitch muscle. Carnosine and creatine has an antioxidant effect and carnosine accounts for about 10% of the muscle's ability to buffer the H+ ions produced by exercise. Objectives: The aim of the study was to investigate the effects of beta alanine and/or creatine supplementation on oxidant and antioxidant status during repeated Wingate tests (WTs). Patients and Methods: Forty four sedentary males participated in the study. Participants performed three 30s WTs with 2 minutes rest between exercise bouts. After the first exercise session, the subjects were assigned to one of four groups: Placebo, Creatine, Beta-alanine and Beta-alanine plus creatine. Participants ingested twice per day for 22 consecutive days, then four times per day for the following 6 days. After the supplementation period the second exercise session was applied. Blood samples were taken before and immediately after the each exercise session for the analysis of oxidative stress and antioxidant markers. Results: Malondialdehyde levels and superoxide dismutase activities were affected by neither supplementation nor exercise. During the pre-supplementation session, protein carbonyl reduced and oxidized glutathione (GSH and GSSG) levels increased immediately after the exercise. However, during the post-supplementation session GSH and GSSG levels increased in beta-alanine and beta-alanine plus creatine groups immediately after the exercise compared to pre-exercise. In addition, during the post-supplementation session total antioxidant capacity increased in beta-alanine group immediately after the exercise. Conclusions: Beta-alanine supplementation has limited antioxidant effect during the repeated WTs. © 2016, Sports Medicine Research Center.en_US
dc.identifier.doi10.5812/asjsm.26843en_US
dc.identifier.issn2008000Xen_US
dc.identifier.issue1en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.urihttps://dx.doi.org/10.5812/asjsm.26843
dc.identifier.urihttps://hdl.handle.net/20.500.12395/34310
dc.identifier.volume7en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherKowsar Medical Publishing Companyen_US
dc.relation.ispartofAsian Journal of Sports Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectAntioxidanten_US
dc.subjectBeta-alanineen_US
dc.subjectCircuit-based exerciseen_US
dc.subjectCreatineen_US
dc.subjectOxidative stressen_US
dc.titleRepeated supramaximal exercise-induced oxidative stress: Effect of ?-Alanine plus creatine supplementationen_US
dc.typeArticleen_US

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