Alerjik rinit patofizyolojisinde oksidatif stres ve antioksidan faktör
Küçük Resim Yok
Tarih
2007
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Amaç: Bu çalışmada, alerjik rinit etyopatogenezinde oksidatif stres ve antioksidanların rolü değerlendirildi. Hastalar ve Yöntemler: Çalışmaya klinik ve laboratuvar incelemeler sonucunda alerjik rinit tanısı konan 40 hasta (13 erkek, 27 kadın; ort. yaş 3014; dağılım 4-63) alındı. Hastaların yakınma süresi ortalama 5.24.9 yıldı. Kan ve serum örneklerinde spektrofotometrik ölçümlerle enzimatik antioksidan olarak miyeloperoksidaz (MPO), non-enzimatik antioksidan olarak A ve E vitamini, oksidatif stres ürünü olan ve lipit peroksidasyonu sonucu oluşan metabolitlerden malondialdehit (MDA) ile oksidatif stres dengesini gösteren total antioksidan kapasiteye bakıldı. Sonuçlar, sağlıklı 40 bireyden oluşan kontrol grubuyla karşılaştırıldı. Bulgular: Hasta grubunda MDA düzeyleri kontrol grubuna göre anlamlı derecede yüksek; MPO, A ve E vitamini düzeyleri ve total antioksidan kapasite anlamlı derecede düşük bulundu (p0.05). Sonuç: Bulgularımız, oksidatif stres ve antioksidan savunma mekanizması arasındaki dengesizliklerin alerjik rinit etyopatogenezinde rol oynayabileceğini düşündürmektedir.
Objectives: We evaluated the role of oxidative stress and antioxidants in the etiopathogenesis of allergic rhinitis. Patients and Methods: The study included 40 patients (13 males, 27 females; mean age 30±14 years; range 4 to 63 years) with allergic rhinitis. The mean symptom duration was 5.2±4.9 years. Blood and serum samples were analyzed spectrophotometrically. Myeloperoxidase (MPO) activity and vitamins A and E were measured as enzymatic and non-enzymatic antioxidants, respectively. Oxidative stress was determined by the malondialdehyde (MDA) level. Total antioxidant capacity (TAC) was measured as the a total antioxidant activity against oxidative stress products. The results were compared with those of a control group consisting of 40 healthy individuals. Results: Compared to the control group, the mean MDA level was significantly higher, and the mean MPO, vitamin A and E levels, and TAC were significantly lower in the patient group (p<0.05). Conclusion: Our results suggest that imbalances between oxidative stress and antioxidant defence mechanisms may play a role in the etiopathogenesis of allergic rhinitis.
Objectives: We evaluated the role of oxidative stress and antioxidants in the etiopathogenesis of allergic rhinitis. Patients and Methods: The study included 40 patients (13 males, 27 females; mean age 30±14 years; range 4 to 63 years) with allergic rhinitis. The mean symptom duration was 5.2±4.9 years. Blood and serum samples were analyzed spectrophotometrically. Myeloperoxidase (MPO) activity and vitamins A and E were measured as enzymatic and non-enzymatic antioxidants, respectively. Oxidative stress was determined by the malondialdehyde (MDA) level. Total antioxidant capacity (TAC) was measured as the a total antioxidant activity against oxidative stress products. The results were compared with those of a control group consisting of 40 healthy individuals. Results: Compared to the control group, the mean MDA level was significantly higher, and the mean MPO, vitamin A and E levels, and TAC were significantly lower in the patient group (p<0.05). Conclusion: Our results suggest that imbalances between oxidative stress and antioxidant defence mechanisms may play a role in the etiopathogenesis of allergic rhinitis.
Açıklama
Anahtar Kelimeler
Cerrahi
Kaynak
Kulak Burun Boğaz İhtisas Dergisi
WoS Q Değeri
Scopus Q Değeri
Cilt
17
Sayı
4
