Vagus nerve stimulation

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dc.contributor.authorEkmekçi H.
dc.contributor.authorKaptan H.
dc.date.accessioned2020-03-26T19:44:05Z
dc.date.available2020-03-26T19:44:05Z
dc.date.issued2017
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractBACKGROUND: The vagus nerve stimulation (vns) is an approach mainly used in cases of intractable epilepsy despite all the efforts. Also, its benefits have been shown in severe cases of depression resistant to typical treatment. AIM: The aim of this study was to present current knowledge of vagus nerve stimulation. MATERIAL AND METHODS: A new value has emerged just at this stage: VNS aiming the ideal treatment with new hopes. It is based on the placement of a programmable generator on the chest wall. Electric signals from the generator are transmitted to the left vagus nerve through the connection cable. Control on the cerebral bioelectrical activity can be achieved by way of these signal sent from there in an effort for controlling the epileptic discharges. RESULTS: The rate of satisfactory and permanent treatment in epilepsy with monotherapy is around 50%. This rate will increase by one-quarters (25%) with polytherapy. However, there is a patient group roughly constituting one-thirds of this population, and this group remains unresponsive or refractory to all the therapies and combined regimes. The more the number of drugs used, the more chaos and side effects are observed. The anti-epileptic drugs (AEDs) used will have side effects on both the brain and the systemic organs. Cerebral resection surgery can be required in some patients. The most commonly encountered epilepsy type is the partial one, and the possibility of benefiting from invasive procedures is limited in most patients of this type. Selective amygdala-hippocampus surgery is a rising value in complex partial seizures. Therefore, as epilepsy surgery can be performed in very limited numbers and rather developed centres, success can also be achieved in limited numbers of patients. The common ground for all the surgical procedures is the target of preservation of memory, learning, speaking, temper and executive functions as well as obtaining a good control on seizures. However, the action mechanism of VNS is still not exactly known. On the other hand, it appears to be a reliable method that is tolerated well in partial resistant seizures. It has been observed that adverse effects are generally of mild-medium severity, and most of the problems can be eliminated easily through the re-adjustment of the stimulator. CONCLUSION: VNS, which is a treatment modality that will take place it deserves in epilepsy treatment with "the correct patient" and "correct reason", must be known better and its applications must be developed. © 2017 Hakan Ekmekçi, Hülagu Kaptan.en_US
dc.identifier.doi10.3889/oamjms.2017.056en_US
dc.identifier.endpage394en_US
dc.identifier.issn1857-5749en_US
dc.identifier.issue3en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage391en_US
dc.identifier.urihttps://dx.doi.org/10.3889/oamjms.2017.056
dc.identifier.urihttps://hdl.handle.net/20.500.12395/35818
dc.identifier.volume5en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherInstitute of Immunobiology and Human Geneticsen_US
dc.relation.ispartofMacedonian Journal of Medical Sciencesen_US
dc.relation.publicationcategoryDiğeren_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectRefractory seizureen_US
dc.subjectTreatment of epilepsyen_US
dc.subjectVagus nerve stimulationen_US
dc.titleVagus nerve stimulationen_US
dc.typeReviewen_US

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