The impact of imiquimod on radiation-induced lung injury: Results of an experimental study

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dc.authorid0000-0001-9963-5724
dc.contributor.authorCalik, Mustafa.
dc.contributor.authorYavaş, Güler.
dc.contributor.authorÇelik, Zeliha Esin.
dc.contributor.authorYavaş, Çağdaş.
dc.contributor.authorCalik, Saniye Goknil.
dc.contributor.authorSargon, Mustafa Fevzi.
dc.contributor.authorEsme, Hidir.
dc.date.accessioned2020-03-26T20:19:30Z
dc.date.available2020-03-26T20:19:30Z
dc.date.issued2019
dc.departmentSelçuk Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractAim: Radiation-induced lung injury (RILI) is a major dose-limiting factor during thoracic irradiation. Imiquimod (Imq) is a heterocyclic amine that has been shown to be effective in diseases related to inflammation and fibrosis. In this study, we aimed to evaluate the impact of Imiquimod on RILI. Material and Method: The study included 60 adult female Wistar-Albino rats (250-300 g). Rats were divided into 6 groups: Group (G) 1: control, G2: radiotherapy (RT) only, G3 and G4: 5 and 10 mg/kg Imq; G5 and G6 RT: plus 5 and 10 mg/kg Imq groups respectively. A single dose of 15 Gray (Gy) RT was given to the lungs. Imq was applied intraperitoneal. Results: The inflammation, fibrosis, and transforming growth factor (TGF)-beta scores of the study groups were significantly different at 6th and 16th week of RT (p < 0.001 for all). At the 6th week of RT, inflammation, fibrosis, and TGF-beta scores did not differ in both RT and non-RT groups. By the 16th week of RT inflammation, fibrosis, and TGF-beta scores were significantly different between G2 and G5, and G2 and G6. Electron microscopy findings supported the results of the light microscopy. Discussion: Although Imq did not improve pneumonitis phase, Imq attenuated radiation-induced lung fibrosis. These findings should be clarified with further preclinical and clinical studies.en_US
dc.identifier.citationCalik, M., Yavaş, G., Çelık, Z. E., Yavaş, Ç., Calık, S. G., Sargon, M. F., Esme, H. (2019). The Impact of Imiquimod on Radiation-Induced Lung Injury: Results of an Experimental Study. The Annals of Clinical and Analytical Medicine, 10(6), 707-713.
dc.identifier.doi10.4328/ACAM.6118en_US
dc.identifier.endpage713en_US
dc.identifier.issn2667-663Xen_US
dc.identifier.issue6en_US
dc.identifier.pmid#YOKen_US
dc.identifier.startpage707en_US
dc.identifier.urihttps://dx.doi.org/10.4328/ACAM.6118
dc.identifier.urihttps://hdl.handle.net/20.500.12395/38294
dc.identifier.volume10en_US
dc.identifier.wosWOS:000514914700013en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.institutionauthorYavaş, Güler.
dc.institutionauthorÇelik, Zeliha Esin.
dc.institutionauthorYavaş, Çağdaş.
dc.language.isoenen_US
dc.publisherBAYRAKOL MEDICAL PUBLISHERen_US
dc.relation.ispartofANNALS OF CLINICAL AND ANALYTICAL MEDICINEen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectImiquimoden_US
dc.subjectFibrosisen_US
dc.subjectLungen_US
dc.subjectPneumoniaen_US
dc.subjectRadiotherapyen_US
dc.titleThe impact of imiquimod on radiation-induced lung injury: Results of an experimental studyen_US
dc.typeArticleen_US

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