Diyabetik hastalarda kalp hızı değişkenliği ile metabolik parametreler ve inflamasyon arasındaki ilişki
Küçük Resim Yok
Tarih
2005
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Amaç: Kalp hızı değişkenliği (KHD) diyabetik hastalarda (DM) otonomik disfonksiyonu göstermede güvenilir parametrelerden biridir. Bu çalışmada DM'ta metabolik ve inflamatuvar parametreler ile KHD arasındaki ilişki gösterilmeye çalışıldı. Metod ve bulgular: Çalışmaya benzer yaş grubundan koroner arter hastalığı ve hipertansiyonu olmayan 40 sağlıklı birey (Grup 1, Ortalama yaş 46 13) ve 80 diyabetik hasta (Grup 2, Ortalama yaş 489) alındı. Tüm olguların 24 saatlik Holter monitörizasyonu ile KHD 'time-domain' parametreleri belirlendi. Grup 2'de açlık kan şekeri (AKŞ), tokluk kan şekeri (TKŞ), hemoglobin A1C (HbAlC), serum insülin düzeyi, idrar mikro-albumin düzeyi, fibrinojen ve C-reaktif protein (CRP) düzeyleri çalışıldı. DM'un süresi belirlendi. KHD'nin 'time domain' parametrelerinin tümü grup 2'de düşüktü (p0.05). Grup 2'de KHD ile AKŞ, TKŞ, HbAIC, insülin, idrar mikroalbumini, diyabetin süresi ve fibrinojen arasında korelasyon yoktu (p0.05). CRP ile KHD (pNN50) arasında negatif korelasyon mevcuttu (r-0.37, p0.05). Sonuç: Bu çalışmada KHD ile DM'un süresi ve metabolik parametreler arasında ilişki belirlenmemiştir. DM'ta KHD'ndeki azalmada inflamatuvar reaksiyonların rolü olabileceği sonucuna varılmıştır.
Purpose: Heart rate variability (HRV) is one of the reliable parameters indicating autonomic dysfunction in diabetic patients. In this study, we investigated the relationship between metabolic and inflammatory param¬eters, and HRV in Diabetes Mellitus (DM). Method and Results: Forty subjects (mean age 46±13, 18 M) without coronary heart disease (CHD) and hypertension (group 1) and 80 diabetic patients (mean age 48±9, 42 M) without CHD and hypertension (group II) with similar age were included in this study. Twenty four hour Holter monitorization and HRV 'time-domain' parameters were calculated in all cases. Fasting blood glucose (FBG) level, postprandial blood glucose (PBG) level, serum insulin level, hemoglobin A1C (HbAlC) level, urine microalbumin level, fibrinogen level, C-reactive protein (CRP) levels were studied in group II. Duration of DM was recorded. All the 'time-domain' parameters were lower in group II than those of group I (p<0.05). In group II, no relation between 1IRV and FBG, PBG, HbAlC, serum insulin, urine microalbumin, fibrinogen, duration of DM was detected (p>0.05); a negative correlation between HRV (pNN50) and CRP was detected. Conclusion; A relationship between HRV and duration of DM and metabolic parameters could not be detected in this study. It has been concluded that inflammatory reactions may have a role in the decreased HRV in DM.
Purpose: Heart rate variability (HRV) is one of the reliable parameters indicating autonomic dysfunction in diabetic patients. In this study, we investigated the relationship between metabolic and inflammatory param¬eters, and HRV in Diabetes Mellitus (DM). Method and Results: Forty subjects (mean age 46±13, 18 M) without coronary heart disease (CHD) and hypertension (group 1) and 80 diabetic patients (mean age 48±9, 42 M) without CHD and hypertension (group II) with similar age were included in this study. Twenty four hour Holter monitorization and HRV 'time-domain' parameters were calculated in all cases. Fasting blood glucose (FBG) level, postprandial blood glucose (PBG) level, serum insulin level, hemoglobin A1C (HbAlC) level, urine microalbumin level, fibrinogen level, C-reactive protein (CRP) levels were studied in group II. Duration of DM was recorded. All the 'time-domain' parameters were lower in group II than those of group I (p<0.05). In group II, no relation between 1IRV and FBG, PBG, HbAlC, serum insulin, urine microalbumin, fibrinogen, duration of DM was detected (p>0.05); a negative correlation between HRV (pNN50) and CRP was detected. Conclusion; A relationship between HRV and duration of DM and metabolic parameters could not be detected in this study. It has been concluded that inflammatory reactions may have a role in the decreased HRV in DM.
Açıklama
Anahtar Kelimeler
Kalp ve Kalp Damar Sistemi
Kaynak
Türk Aritmi Pacemaker ve Elektrofizyoloji Dergisi
WoS Q Değeri
Scopus Q Değeri
Cilt
3
Sayı
1
