The Effects of Acetylsalicylic Acid on the Phagocytic Function of Bovine Neutrophils in Vitro

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dc.contributor.authorBaş, A. L.
dc.contributor.authorTraş, B.
dc.contributor.authorElmas, M.
dc.contributor.authorKeskin, E.
dc.contributor.authorYazar, E.
dc.date.accessioned2020-03-26T16:26:23Z
dc.date.available2020-03-26T16:26:23Z
dc.date.issued1998
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractAcetylsalicylic acid (ASA), a cyclooxygenase inhibitor, has been used for its analgesic and antiinflammatory properties. Its stimulating effect on the immune system has recently been described. In the present study, the effect of ASA on phagocytic and microbicidal activity was investigated in vitro at the concentrations of 50, 100, 150, 250 and 500 mu g/ml in the peripheral blood polymorphonuclear leucocytes (PMNL) of twelve healthy Holstein heifers. The functions of PMNL were evaluated with flourescent microscopy using flourochrome dye, acridine orange. In this study, all the results compared to the controls at the concentrations of 50, 100 and 150 mu g/ml of ASA revealed that phagocytosis increased from 74.25 % to 80.3, 80.5 and 83.7 %, respectively. There was a statistically significant decrease of phagocytic activity of PMNL between the 500 mu g/ml of ASA and control group. In addition to this, the microbicidal activity increased at the dose of 50 mu g/ml of ASA (97.1 %). Whereas there was a decrease at doses of 250 (87.4 %) and 500 mu g/ml of ASA (87.3 %) compared with the control group (92.2 %). The results of the in vitro experiments showed that the function of bovine polymorphonuclear leucocytes was altered by different concentrations of acetylsalicylic acid.en_US
dc.identifier.endpage+en_US
dc.identifier.issn0035-1555en_US
dc.identifier.startpage857en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12395/16806
dc.identifier.volume149en_US
dc.identifier.wosWOS:000076562600006en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherECOLE NATIONAL VET TOULOUSEen_US
dc.relation.ispartofRevue De Medecine Veterinaireen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectacetylsalicylic aciden_US
dc.subjectpolymorphonuclear leucocytesen_US
dc.subjectphagocytic functionen_US
dc.subjectbovineen_US
dc.titleThe Effects of Acetylsalicylic Acid on the Phagocytic Function of Bovine Neutrophils in Vitroen_US
dc.typeArticleen_US

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